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T Cells Seen from the Metabolic and Aging Perspective

  • Xavier Camous
  • Anis LarbiEmail author
Chapter

Abstract

Ageing is often associated with impaired immunity accompanied by a higher susceptibility to infections, cancers, autoimmune disorders, and inflammatory conditions such as metabolic syndrome. However, how the immune system ages, independently of chronological age, is still not fully understood. Immunological challenges through life may cause the immune system to change its composition and to adapt to changes of the other systems (CNS, endocrine, cardiovascular). The age-related changes at the T cell level are very striking. This chapter reviews how the functionality of the different populations is associated to different metabolic pathways. This chapter highlights the importance of understanding metabolic changes at the cellular level to better evaluate T cell senescence in humans.

Keywords

West Nile Virus Lipid Raft Dwarf Mouse Thymic Involution Immune Synapse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Singapore Immunology Network (SIgN)Agency for Science Technology and ResearchSingaporeSingapore

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