Biological and Phenotypic Alterations of T Cells in Aging
The deleterious effects of ageing on the T cell compartment are well studied, as they lead to increased susceptibility to infections, cancers, and autoimmunity in elders. Ageing reduces the number and T cell potential of hematopoietic precursors, and involution of the thymus renders it less capable of supporting de novo T cell development. Consequently, ageing compromises the functions of lymphocytes, resulting in a T cell pool with restricted receptor specificity and fewer naïve T cells.
KeywordsGrowth Hormone Hematopoietic Stem Cell Transplantation Memory Cell Clonal Expansion Young Cell
- Pae M, Meydani SN, Wu D (2012) The role of nutrition in enhancing immunity in aging. Ageing Dis 3(1):91–129Google Scholar