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Biological and Phenotypic Alterations of T Cells in Aging

  • Ahmad MassoudEmail author
  • Amir Hossein Massoud
Chapter

Abstract

The deleterious effects of ageing on the T cell compartment are well studied, as they lead to increased susceptibility to infections, cancers, and autoimmunity in elders. Ageing reduces the number and T cell potential of hematopoietic precursors, and involution of the thymus renders it less capable of supporting de novo T cell development. Consequently, ageing compromises the functions of lymphocytes, resulting in a T cell pool with restricted receptor specificity and fewer naïve T cells.

Keywords

Growth Hormone Hematopoietic Stem Cell Transplantation Memory Cell Clonal Expansion Young Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Alam I, Larbi A, Pawelec G (2012) Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan. Immun Ageing 9(1):16PubMedCrossRefGoogle Scholar
  2. Alvarado C, Alvarez P, Puerto M et al (2006) Dietary supplementation with antioxidants improves functions and decreases oxidative stress of leukocytes from prematurely aging mice. Nutrition 22(7–8):767–777PubMedCrossRefGoogle Scholar
  3. Behzad H, Huckriede AL, Haynes L et al (2012) GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults. J Infect Dis 205(3):466–473PubMedCrossRefGoogle Scholar
  4. Chen BJ, Cui X, Sempowski GD et al (2003) Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. Exp Hematol 31(10):953–958PubMedCrossRefGoogle Scholar
  5. Chen BJ, Deoliveira D, Spasojevic I et al (2010) Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One 5(6):e11056PubMedCrossRefGoogle Scholar
  6. Chidgey AP, Boyd RL (2006) Stemming the tide of thymic aging. Nat Immunol 7(10):1013–1016PubMedCrossRefGoogle Scholar
  7. Chou JP, Effros RB (2013) T cell replicative senescence in human aging. Curr Pharm Des 19(9):1680–1698PubMedGoogle Scholar
  8. Curtsinger JM, Schmidt CS, Mondino A et al (1999) Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol 162(6):3256–3262PubMedGoogle Scholar
  9. Douziech N, Seres I, Larbi A et al (2002) Modulation of human lymphocyte proliferative response with aging. Exp Gerontol 37(2–3):369–387PubMedCrossRefGoogle Scholar
  10. Eaton SM, Maue AC, Swain SL et al (2008) Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses. J Immunol 181(7):4825–4831PubMedGoogle Scholar
  11. Effros RB (2003) Genetic alterations in the ageing immune system: impact on infection and cancer. Mech Ageing Dev 124(1):71–77PubMedCrossRefGoogle Scholar
  12. Engwerda CR, Fox BS, Handwerger BS (1996) Cytokine production by T lymphocytes from young and aged mice. J Immunol 156(10):3621–3630PubMedGoogle Scholar
  13. Goldberg GL, Sutherland JS, Hammet MV et al (2005) Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation. Transplantation 80(11):1604–1613PubMedCrossRefGoogle Scholar
  14. Goldberg GL, Alpdogan O, Muriglan SJ et al (2007) Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation. J Immunol 178(11):7473–7484PubMedGoogle Scholar
  15. Haynes L, Swain SL (2006) Why aging T cells fail: implications for vaccination. Immunity 24(6):663–666PubMedCrossRefGoogle Scholar
  16. Haynes L, Linton PJ, Eaton SM et al (1999) Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med 190(7):1013–1024PubMedCrossRefGoogle Scholar
  17. Haynes L, Eaton SM, Burns EM et al (2003) CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci U S A 100(25):15053–15058PubMedCrossRefGoogle Scholar
  18. Haynes L, Eaton SM, Burns EM et al (2004) Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J Immunol 172(9):5194–5199PubMedGoogle Scholar
  19. Heng TS, Chidgey AP, Boyd RL (2010) Getting back at nature: understanding thymic development and overcoming its atrophy. Curr Opin Pharmacol 10(4):425–433PubMedCrossRefGoogle Scholar
  20. Henson SM, Akbar AN (2010) Memory T-cell homeostasis and senescence during aging. Adv Exp Med Biol 684:189–197PubMedGoogle Scholar
  21. High KP, Akbar AN, Nikolich-Zugich J (2012) Translational research in immune senescence: assessing the relevance of current models. Semin Immunol 24(5):373–382PubMedCrossRefGoogle Scholar
  22. Hobbs MV, Ernst DN, Torbett BE et al (1991) Cell proliferation and cytokine production by CD4+ cells from old mice. J Cell Biochem 46(4):312–320PubMedCrossRefGoogle Scholar
  23. Holland AM, van den Brink MR (2009) Rejuvenation of the aging T cell compartment. Curr Opin Immunol 21(4):454–459PubMedCrossRefGoogle Scholar
  24. Hosaka N, Nose M, Kyogoku M et al (1996) Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+mice. Proc Natl Acad Sci U S A 93(16):8558–8562PubMedCrossRefGoogle Scholar
  25. Kapasi ZF, Murali-Krishna K, McRae ML et al (2002) Defective generation but normal maintenance of memory T cells in old mice. Eur J Immunol 32(6):1567–1573PubMedCrossRefGoogle Scholar
  26. Kaszubowska L (2008) Telomere shortening and ageing of the immune system. J Physiol Pharmacol 59(Suppl 9):169–186PubMedGoogle Scholar
  27. Kilpatrick RD, Rickabaugh T, Hultin LE et al (2008) Homeostasis of the naive CD4+ T cell compartment during aging. J Immunol 180(3):1499–1507PubMedGoogle Scholar
  28. Klinman NR, Kline GH (1997) The B-cell biology of aging. Immunol Rev 160:103–114PubMedCrossRefGoogle Scholar
  29. Kwon TK, Nagel JE, Buchholz MA et al (1996) Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1. Gene 180(1–2):113–120PubMedCrossRefGoogle Scholar
  30. Lee N, Shin MS, Kang I (2012) T-cell biology in aging, with a focus on lung disease. J Gerontol A Biol Sci Med Sci 67(3):254–263PubMedCrossRefGoogle Scholar
  31. Linton PJ, Dorshkind K (2004) Age-related changes in lymphocyte development and function. Nat Immunol 5(2):133–139PubMedCrossRefGoogle Scholar
  32. Lustyik G, O’Leary JJ (1989) Aging and the mobilization of intracellular calcium by phytohemagglutinin in human T cells. J Gerontol 44(2):B30–B36PubMedCrossRefGoogle Scholar
  33. Maue AC, Eaton SM, Lanthier PA et al (2009) Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J Immunol 182(10):6129–6135PubMedCrossRefGoogle Scholar
  34. McLeod JD (2000) Apoptotic capability in ageing T cells. Mech Ageing Dev 121(1–3):151–159PubMedGoogle Scholar
  35. Minematsu T, Yamamoto Y, Nagase T et al (2011) Aging enhances maceration-induced ultrastructural alteration of the epidermis and impairment of skin barrier function. J Dermatol Sci 62(3):160–168PubMedCrossRefGoogle Scholar
  36. Noble JM, Ford GA, Thomas TH (1999) Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes. Clin Sci (Lond) 97(3):323–329CrossRefGoogle Scholar
  37. Pae M, Meydani SN, Wu D (2012) The role of nutrition in enhancing immunity in aging. Ageing Dis 3(1):91–129Google Scholar
  38. Ponnappan U (2002) Ubiquitin-proteasome pathway is compromised in CD45RO + and CD45RA + T lymphocyte subsets during aging. Exp Gerontol 37(2–3):359–367PubMedCrossRefGoogle Scholar
  39. Santiago AF, Alves AC, Oliveira RP et al (2011) Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa. Immunobiology 216(10):1085–1093PubMedCrossRefGoogle Scholar
  40. Sempowski GD, Gooding ME, Liao HX et al (2002) T cell receptor excision circle assessment of thymopoiesis in aging mice. Mol Immunol 38(11):841–848PubMedCrossRefGoogle Scholar
  41. Strasser A, Sonnek U, Niedermuller H (1997) Age-related changes in plasma IgM level after SRBC-stimulation in the rat. Arch Gerontol Geriatr 25(3):277–284PubMedCrossRefGoogle Scholar
  42. Tamura T, Kunimatsu T, Yee ST et al (2000) Molecular mechanism of the impairment in activation signal transduction in CD4(+) T cells from old mice. Int Immunol 12(8):1205–1215PubMedCrossRefGoogle Scholar
  43. von Freeden-Jeffry U, Solvason N, Howard M et al (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7(1):147–154CrossRefGoogle Scholar
  44. Weinberger B, Grubeck-Loebenstein B (2012) Vaccines for the elderly. Clin Microbiol Infect 18(Suppl 5):100–108PubMedCrossRefGoogle Scholar
  45. Welniak LA, Sun R, Murphy WJ (2002) The role of growth hormone in T-cell development and reconstitution. J Leukoc Biol 71(3):381–387PubMedGoogle Scholar
  46. Zhou X, McElhaney JE (2011) Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine 29(11):2169–2177PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran
  2. 2.Department of Microbiology and ImmunologyMcGill UniversityMontrealCanada
  3. 3.Meakins-Christie LaboratoriesMcGill UniversityMontrealCanada

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