Biological and Phenotypic Alterations of T Cells in Aging

  • Ahmad MassoudEmail author
  • Amir Hossein Massoud


The deleterious effects of ageing on the T cell compartment are well studied, as they lead to increased susceptibility to infections, cancers, and autoimmunity in elders. Ageing reduces the number and T cell potential of hematopoietic precursors, and involution of the thymus renders it less capable of supporting de novo T cell development. Consequently, ageing compromises the functions of lymphocytes, resulting in a T cell pool with restricted receptor specificity and fewer naïve T cells.


Growth Hormone Hematopoietic Stem Cell Transplantation Memory Cell Clonal Expansion Young Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran
  2. 2.Department of Microbiology and ImmunologyMcGill UniversityMontrealCanada
  3. 3.Meakins-Christie LaboratoriesMcGill UniversityMontrealCanada

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