T Cell-Mediated Immunity in the Immunosenescence Process

  • Pierre Olivier LangEmail author


Immunosenescence contributes to render older adults more susceptible to pathogens and to develop main age-related diseases. With the ever-increasing rise in the number and proportion of older persons worldwide, one of the challenges of a “long-life society” is to ensure that the years gained are not only healthy and disability-free years but also offering a good quality of life. In this perspective, recent research has concentrated on identifying the factors hindering healthy ageing, and among them, the age-related changes of the immune system have thus been particularly investigated. With respect to its central role in orchestrating the immune response, this chapter describes the main features of T cell-mediated immune senescence and the underlying mechanisms contributing to this state of increased vulnerability. Furthermore, it will explore the means by which T cell functions could be identified by using biomarkers.


Treg Cell Herpes Zoster Influenza Vaccination Senescent Cell Thymic Involution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Nescens Centre of Preventive Medicine, Clinique of GenolierGenolierSwitzerland
  2. 2.Translational Medicine Research Group, School of HealthCranfield UniversityCranfieldUK

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