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An Introduction on the Old Age and the Aging of the Immune System

  • Mohamad Bagher EslamiEmail author
Chapter

Abstract

The immune system is vital for the well-being and general health of all individuals, especially elderly, while like other systems it undergoes several changes during aging. Aging influence not only the renewal potential of this system but also the elements of the cytokine network essential for communication between its different parts. It is therefore very necessary to acquire more knowledge on the effects of aging on this highly complex system. Although, there is a growing body of literature on this field, there are far more controversial and unresolved subjects in need of further research. The well-being, health of the old people, and possible restoration of the potential of this system rely largely on the valuable knowledge remained to be gained by further research on this subject.

References

  1. Goronzy JJ, Weyand CM (2012) Immune aging and autoimmunity. Cell Mol Life Sci 69(10):1615–1623PubMedCrossRefGoogle Scholar
  2. Goronzy JJ, Fujii H, Weyand CM (2006) Telomeres, immune aging and autoimmunity. Exp Gerontol 41(3):246–251PubMedCrossRefGoogle Scholar
  3. Grubeck-Loebenstein B, Wick G (2002) The aging of the immune system. Adv Immunol 80:243–284PubMedGoogle Scholar
  4. Hohensinner PJ, Goronzy JJ, Weyand CM (2012) Telomere dysfunction, autoimmunity and aging. Aging Dis 2(6):524–537Google Scholar
  5. Huang H, Patel DD, Manton KG (2005) The immune system in aging: roles of cytokines, T cells and NK cells. Front Biosci 10:192–215PubMedCrossRefGoogle Scholar
  6. Kaszubowska L (2008) Telomere shortening and ageing of the immune system. J Physiol Pharmacol 59(Suppl 9):169–186PubMedGoogle Scholar
  7. Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G (2008) Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) 23:64–74CrossRefGoogle Scholar
  8. Pahlavani MA (2000) Immune dysfunction in the elderly: the role of nutrition. Iran J Allergy Asthma Immunol 1(3):117–127Google Scholar
  9. Rymkiewicz PD, Heng YX, Vasudev A, Larbi A (2012) The immune system in the aging human. Immunol Res 53(1–3):235–250PubMedCrossRefGoogle Scholar
  10. Sanders JL, Newman AB (2013) Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev 35(1):112–131CrossRefGoogle Scholar
  11. Seppet E, Paasuke M, Conte M, Capri M, Franceschi C (2011) Ethical aspects of aging research. Biogerontology 12(6):491–502PubMedCrossRefGoogle Scholar
  12. Weiskopf D, Weinberger B, Grubeck-Loebenstein B (2009) The aging of the immune system. Transpl Int 22(11):1041–1050PubMedCrossRefGoogle Scholar
  13. Weng NP (2006) Aging of the immune system: how much can the adaptive immune system adapt? Immunity 24(5):495–499PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Immunology Division, Pathobiology Department, School of Public HealthTehran University of Medical SciencesTehranIran

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