Novel Chromatic Pupillometer: Portable Pupillometry Diagnostic System

  • Peyton Paulick
  • Philipp Novotny
  • Mark Bachman
  • Herbert Plischke
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8019)


This research study explores development of a novel chromatic pupillometer that can analyze the characteristics of a patient’s pupil light reflex (PLR). Characteristics of the PLR are not only used to determine retinal function but also have been recently used as a non-invasive diagnostic for a variety of neurological disorders and diseased states. This device is a compact diagnostic goggle that contains both stimulating and recording abilities of the PLR. This paper will discuss the design and function of the prototype as well as present preliminary data on evaluation of a subset of cells within the PLR.


chromatic pupillometry pupil light reflex ipRGCs pupillometry eye tracking assistive device portable system 


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  1. 1.
    Herbst, Sander, B., Milea, D., Lund-Andersen, H., Kawasaki, A.: Test-retest repeatability of the pupil light response to blue and red light stimuli in normal human eyes using a novel pupillometer. Frontiers in Neurology 2, 10 (2011)CrossRefGoogle Scholar
  2. 2.
    Kawasaki, A., Munier, F.L., Leon, L., Kardon, R.H.: Pupillometric quantification of residual rod and cone activity in leber congenital amaurosis. Archives of Ophthalmology 130(6), 798–800 (2012)CrossRefGoogle Scholar
  3. 3.
    Park, J.C., Moura, A.L., Raza, A.S., Rhee, D.W., Kardon, R.H.: Toward a Clinical Protocol for Assessing Rod, Cone, and Melanopsin Contributions to the Human Pupil Response, pp. 6624–6635 (2011)Google Scholar
  4. 4.
    Kardon, R., Anderson, S.C., Damarjian, T.G., Grace, E.M., Stone, E., Kawasaki, A.: Chromatic pupillometry in patients with retinitis pigmentosa. Ophthalmology 118(2), 376–381 (2011)CrossRefGoogle Scholar
  5. 5.
    Zele, A.J., Feigl, B., Smith, S.S., Markwell, E.L.: The circadian response of intrinsically photosensitive retinal ganglion cells. PloS One 6(3), e17860 (2011)CrossRefGoogle Scholar
  6. 6.
    Stergiou, V., et al.: Pupillometric findings in patients with Parkinson’s disease and cognitive disorder 72, 97–101 (2009)Google Scholar
  7. 7.
    Fotiou, D.F., Stergiou, V., Tsiptsios, D., Lithari, C., Nakou, M., Karlovasitou, A.: Cholinergic deficiency in Alzheimer’s and Parkinson’s disease: evaluation with pupillometry. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology 73(2), 143–149 (2009)CrossRefGoogle Scholar
  8. 8.
    Shindler, K.S., Revere, K., Dutt, M., Ying, G.-S., Chung, D.C.: In vivo detection of experimental optic neuritis by pupillometry. Experimental Eye Research 100, 1–6 (2012)CrossRefGoogle Scholar
  9. 9.
    Dütsch, M., Marthol, H., Michelson, G., Neundörfer, B., Hilz, M.J.: Pupillography refines the diagnosis of diabetic autonomic neuropathy. Journal of the Neurological Sciences 222(1-2), 75–81 (2004)CrossRefGoogle Scholar
  10. 10.
    Diego, S., Hospital, L.E.: Quantitative pupillometry, a new technology: normative data and preliminary observations in patients with acute head injury. Technical note. Journal of Neurosurgery 98(1), 205–213 (2003)CrossRefGoogle Scholar
  11. 11.
    Gamlin, P.D.R., McDougal, D.H., Pokorny, J., Smith, V.C., Yau, K.-W., Dacey, D.M.: Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells. Vision Research 47(7), 946–954 (2007)CrossRefGoogle Scholar
  12. 12.
    Kardon, R., Anderson, S.C., Damarjian, T.G., Grace, E.M., Stone, E., Kawasaki, A.: Chromatic pupil responses: preferential activation of the melanopsin-mediated versus outer photoreceptor-mediated pupil light reflex. Ophthalmology 116(8), 1564–1573 (2009)CrossRefGoogle Scholar
  13. 13.
    Lockley, S.W., Skene, D.J., Arendt, J., Tabandeh, H., Bird, A.C., Defrance, R.: Relationship between melatonin rhythms and visual loss in the blind. The Journal of Clinical Endocrinology and Metabolism 82(11), 3763–3770 (1997)Google Scholar
  14. 14.
    Besch, D., et al.: Extraocular surgery for implantation of an active subretinal visual prosthesis with external connections: feasibility and outcome in seven patients. The British Journal of Ophthalmology 92(10), 1361–1368 (2008)CrossRefGoogle Scholar
  15. 15.
    Purves, D., Augustine, G.J., Fitzpatrick, D., Hall, W.C., LaMantia, A.S., McNamara, J.O., White, L.E.: Neuroscience, 4th edn. Sinauer Associates (2008)Google Scholar
  16. 16.
    Winkler: Titanium Dioxide. European Coatings Literature (2003)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Peyton Paulick
    • 1
  • Philipp Novotny
    • 2
  • Mark Bachman
    • 1
  • Herbert Plischke
    • 2
  1. 1.Department of Biomedical EngineeringUniversity of California IrvineIrvineUSA
  2. 2.Generation Research Program der Ludwig-Maximilians Universität MünchenBad TölzGermany

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