This study examined the effects of 32 h of continuous SD(Sleep Deprivation) on cognitive behavior in simulated flight. Four subjects who were skilled in flight simulator took part in the experiment. Eye movement and flight parameters were measured in the following 5 time periods: 1100 on DAY 1, 1500, 0400 on DAY 2, 1100, and 1500. Subject’s cognitive workload and fatigue were assessed with method of NASA-TLX (national aeronautics and space administration-task load index) and RPE (rating of perceived exertion). Eye movement indices of average pupil area, average saccade amplitude and average saccade velocity decreased during the 32 h SD and they all showed significantly changes in the final SD while the index of average fixation time increased in the final SD. Flight performance that evaluated by four flight parameters of the deviation of height, pitch angle, yaw angle and tilt angle deteriorated during the 32 h SD, but not significantly. The feeling of fatigue and workload reported by subjects both increased during the 32 h SD. Effects of daily rhythm were also found, there were a obviously change at the hour of 0400. 32 h of SD has obvious effects on eye movement behaviors which have close relations to fatigue because of SD. The eye movement measurement can be served as a tool to continually monitor fatigue online.


sleep deprivation cognition eye movement flight performance 


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  1. 1.
    Lopez, N., Previc, F.H., Fischer, G., et al.: Effects of sleep deprivation on cognitive performance by United States Air Force pilots. Journal of Applied Research in Memory and Cognition 1, 27–73 (2012)CrossRefGoogle Scholar
  2. 2.
    Killgore, W.D.: Effects of sleep deprivation on cognition. Progress in Brain Research 185, 105–129 (2010)CrossRefGoogle Scholar
  3. 3.
    Whitney, P., Hinson, J.M.: Measurement of cognition in studies of sleep deprivation. Progress in Brain Research 185, 37–48 (2010)CrossRefGoogle Scholar
  4. 4.
    Kim, H.J., Kim, H., Park, K.D., Choi, K.G., Lee, H.W.: A survey of sleep deprivation patterns and their effects on cognitive functions of residents and interns in Korea. Sleep Medicine 12, 390–396 (2011)CrossRefGoogle Scholar
  5. 5.
    Tomasko, J.M., Pauli, E.M., Kunselman, A.R., Haluck, R.S.: Sleep deprivation increases cognitive workload during simulated surgical tasks. The American Journal of Surgery 203, 37–43 (2012)CrossRefGoogle Scholar
  6. 6.
    Perry, I.C.: Helicopter aircrew fatigue. AGARD Advisory Report No. 69Google Scholar
  7. 7.
    Cao, X.L.: Experimental Study of the Attention Character and Subjective Assessment Methods on Mental Fatigue. PhD thesis of the Fourth Military University (2003) (in Chinese)Google Scholar
  8. 8.
    Belyavin, A., Wright, N.A.: Changes in electrical activity of the brain with vigilance. Electroencephalograph. Clin. Neurophysiology 66(2), 137–144 (1987)CrossRefGoogle Scholar
  9. 9.
    Fernstrom, J.D., Fernstrom, M.H.: Exercise, serum free tryptophan, and central fatigue. The Journal of Nutrition 136(2), 553–559 (2006)Google Scholar
  10. 10.
    Ohta, M., Hirai, N., Ono, Y., et al.: Clinical biochemical evaluation of central fatigue with 24-hour continuous exercise. The Japanese Journal of Clinical Pathology 53(9), 802–809 (2005)Google Scholar
  11. 11.
    Zhang, Q., Cheng, J.N., Yang, P.J., et al.: Preliminary Study on Balance Function Quantitative Assessment in Human. Chinese Journal of Rehabilitation 13(2), 49–52 (1998) (in Chinese)Google Scholar
  12. 12.
    Wang, S.Y., Zhang, L.F., Cheng, J.H., Wang, X.B.: Time-frequency analysis of heart rate variability during head up tilt. Journal of the Fourth Military Medical University 22(4), 301–305 (2001) (in Chinese)Google Scholar
  13. 13.
    Ji, H.G., Zhang, L., Wang, H.M.: Functional change after 24 hour sleep deprivation. Chinese Journal of Behavioral Medical Science 7(4), 258–259 (1998)Google Scholar
  14. 14.
    Yue, P., Miao, D.M., Huang, P.E., et al.: Influence of 32-hour sleep deprivation on selective attention. Journal of Fourth Military Medical University 25(4), 378–381 (2004)Google Scholar
  15. 15.
    Previc, F.H., Lopez, N., Ercoline, W.R., et al.: The Effects of Sleep Deprivation on Flight Performance, Instrument Scanning, and Physiological Arousal in Pilots. The International Journal of Aviation Psychology 19(4), 326–346 (2009)CrossRefGoogle Scholar
  16. 16.
    Bailes, S., Libman, E., Baltzan, M., et al.: Brief and distinct empirical sleepiness and fatigue scales. Journal of Psychosomatic Research 60, 605–613 (2006)CrossRefGoogle Scholar
  17. 17.
    Lowenstein, O., Locwenficld, I.E.: The sleep-waking cycle and pupillary activity. Animals of the New York Academy of Sciences 117, 142–156 (1964)CrossRefGoogle Scholar
  18. 18.
    Russo, M., Thomas, M., Sing, H., et al.: Saccadic velocity and pupil constriction latency changes in partial sleep deprivation, and correlations with simulated motor vehicle crashes. Sleep 22(1), 297–298 (1999)Google Scholar
  19. 19.
    Gennaro, L.D., Ferrara, M., Urbani, L., et al.: Oculomotor impairment after 1 night of total sleep deprivation: a dissociation between measures of speed and accuracy. Clinical Neurophysiology 111(10), 1771–1778 (2000)CrossRefGoogle Scholar
  20. 20.
    Schleicher, R., Galley, N.: Blinks and saccades as indicators of fatigue in sleepiness warners: looking tired? Ergonomics 51(7), 982–1010 (2008)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Zhong-Qi Liu
    • 1
  • Qian-Xiang Zhou
    • 1
  • Fang Xie
    • 2
  1. 1.School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina
  2. 2.General Technology DepartmentChina North Vehicle Research InstituteBeijingChina

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