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Development of Patch Clamping

  • Majid MalboubiEmail author
  • Kyle Jiang
Chapter
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)

Abstract

Patch clamping was first introduced into biophysical studies by Neher and Sakmann [1] in 1976 and was soon expanded to many other fields such as biology and medicine. The technique not only allowed the detection of single-channel currents in biological membranes for the first time but also enabled higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches [2]. The development of the patch clamp method was honoured with a Nobel Prize in 1991.

Keywords

Patch Clamp Patch Pipette Glass Micropipette Outer Channel Planar Patch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Author(s) 2014

Authors and Affiliations

  1. 1.London Centre for NanotechnologyLondonUK
  2. 2.School of Mechanical EngineeringThe University of BirminghamBirminghamUK

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