Development of Patch Clamping

  • Majid MalboubiEmail author
  • Kyle Jiang
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)


Patch clamping was first introduced into biophysical studies by Neher and Sakmann [1] in 1976 and was soon expanded to many other fields such as biology and medicine. The technique not only allowed the detection of single-channel currents in biological membranes for the first time but also enabled higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches [2]. The development of the patch clamp method was honoured with a Nobel Prize in 1991.


Patch Clamp Patch Pipette Glass Micropipette Outer Channel Planar Patch 
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Copyright information

© The Author(s) 2014

Authors and Affiliations

  1. 1.London Centre for NanotechnologyLondonUK
  2. 2.School of Mechanical EngineeringThe University of BirminghamBirminghamUK

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