Dimensional Reduction of Cardiac Models for Effective Validation and Calibration

  • Matthieu Caruel
  • Radomir Chabiniok
  • Philippe Moireau
  • Yves Lecarpentier
  • Dominique Chapelle
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7945)


Complex 3D beating heart models are now available, but their complexity makes calibration and validation very difficult tasks. We thus propose a systematic approach of deriving simplified reduced-dimensional models, in “0D” – typically, to represent a cardiac cavity, or several coupled cavities – and in “1D” – to model elongated structures such as fibers or myocytes. As illustrations of our approach, we demonstrate model validation based on experiments performed with papillary muscles, and calibration using patient-specific pressure-volume loops.


Dimensional Reduction Papillary Muscle Myosin Head Couple Cavity Cardiac Cavity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Matthieu Caruel
    • 1
  • Radomir Chabiniok
    • 2
  • Philippe Moireau
    • 1
  • Yves Lecarpentier
    • 3
    • 4
  • Dominique Chapelle
    • 1
  1. 1.M∃DISIM TeamInria Saclay Ile-de-FrancePalaiseauFrance
  2. 2.Division of Imaging Sciences & Biomedical EngineeringSt Thomas’ Hospital, King’s College LondonUK
  3. 3.Institut du CoeurHôpital de la Pitié-SalpêtrièreParisFrance
  4. 4.Centre de Recherche CliniqueHôpital de MeauxFrance

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