An Inverse Spectral Method to Localize Discordant Alternans Regions on the Heart from Body Surface Measurements

  • Jaume Coll-Font
  • Burak Erem
  • Alain Karma
  • Dana H. Brooks
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7945)


Spatially discordant T-wave alternans (TWA) has been shown to be linked to the genesis of ventricular fibrillation. Identification of discordant TWA through spatial characterization of TWA patterns in the heart has the potential to improve sudden cardiac death risk stratification. In this paper we present a method to solve a new variant of the inverse problem in electrocardiography that is tailored to estimate the TWA regions on the heart from non-invasive measurements on the body surface. We evaluate our method using both body surface potentials synthesized from heart surface potentials generated with ECGSIM and from potentials measured on a canine heart, and we show that this method detects the main regions in the heart undergoing TWA.


Inverse Problem Spectral Method Inverse Solution Temporal Regularization Sudden Cardiac Death Risk 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Jaume Coll-Font
    • 1
  • Burak Erem
    • 1
  • Alain Karma
    • 2
  • Dana H. Brooks
    • 1
  1. 1.B-Spiral Group, Dept. of ECENortheastern UniversityBostonUSA
  2. 2.Physics Dept.Northeastern UniversityBostonUSA

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