Initial Experience with a Dynamic Imaging-Derived Immersed Boundary Model of Human Left Ventricle
Understanding the myocardial biomechanics of the left ventricle (LV) in health and disease is important for improving patient risk stratification and management. Computational models of the heart are able to provide insights into the mechanics of heart function. In this study, we develop a dynamic human LV model using an immersed boundary (IB) method along with a finite element description of myocardial mechanics. Our results show that this computational model is able to simulate LV dynamics from end-diastole to end-systole, and that the model results are in reasonably good agreement with noninvasive in vivo strain measurements obtained by magnetic resonance (MR) imaging.
KeywordsRadial Strain Immerse Boundary Method Magnetic Resonance Cine Image Deformable Image Registration Myocardial Mechanic
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- 1.Allan, A., Gao, H., McComb, C., Berry, C.: Myocardial strain estimated from standard cine MRI closely represents strain estimated from dedicated strain-encoded MRI. In: 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2011), pp. 2650–2653. IEEE (2011)Google Scholar
- 3.Griffith, B., Luo, X.: Hybrid finite difference/finite element version of the immersed boundary method (submitted)Google Scholar
- 14.Wang, H., Gao, H., Luo, X., Berry, C., Griffith, B., Ogden, R., Wang, T.: Structure-based finite strain modelling of the human left ventricle in diastole. Int. J. Numer. Meth. Biomed. Eng. (2012)Google Scholar
- 16.Zhang, Z., Sun, K., Saloner, D., Wallace, A., Ge, L., Baker, A., Guccione, J., Ratcliffe, M.: The benefit of enhanced contractility in the infarct borderzone: a virtual experiment. Front. Physiol. 3 (2012)Google Scholar