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The Control Analysis of Signal Transduction

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Book cover Systems Biology of Metabolic and Signaling Networks

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 16))

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Abstract

This chapter discusses how metabolic control analysis (MCA) and generalisations thereof such as hierarchical control analysis (HCA) may help to understand the control of cell function through signal transduction, as well as the control of signal transduction itself. It reviews the key concepts of MCA paying attention to their applicability to signal transduction. Control analysis has already led to major insights into signal transduction such as that control of signalling tends to be distributed over multiple components and that the phosphatases are as important as, or more important than, the kinases. Examples of applications of control analysis in the medical domain are discussed.

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Acknowledgement

HVW, MV, and SR thank the transnational program Systems Biology of MicroOrganisms (SysMO) and ERASysBioprogram and its funders EPSRC/BBSRC for supporting the following projects (R111828, MOSES project, ERASysBio, BB/F003528/1, BB/C008219/1, BB/F003544/1, BB/I004696/1, BB/I00470X/1, BB/I017186/1, EP/D508053/1, BB/I017186/1). HVW also thanks other contributing funding sources including the NWO, and EU-FP7 (EC-MOAN, UNICELLSYS, SYNPOL, ITFOM).

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Authors and Affiliations

  1. Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, School for Chemical Engineering and Analytical Science, University of Manchester, Manchester, M1 7DN, UK

    Hans V. Westerhoff, Samrina Rehman & Malkhey Verma

  2. Synthetic Systems Biology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands

    Hans V. Westerhoff

  3. Department of Molecular Cell Biology, Netherlands Institute for Systems Biology, VU University Amsterdam, Amsterdam, The Netherlands

    Hans V. Westerhoff, Fred C. Boogerd & Nilgun Yilmaz

Authors
  1. Hans V. Westerhoff
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  2. Samrina Rehman
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  3. Fred C. Boogerd
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  4. Nilgun Yilmaz
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  5. Malkhey Verma
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Correspondence to Hans V. Westerhoff .

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Editors and Affiliations

  1. School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

    Miguel A. Aon

  2. Laboratory of Fundamental and Applied Bi, Inserm U1055 and University Joseph Fourier, Grenoble, Grenoble cedex 9, France

    Valdur Saks

  3. Laboratory of Fundamental and Applied Bi, Inserm U1055 and University Joseph Fourier, Grenoble, Grenoble cedex 9, France

    Uwe Schlattner

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Westerhoff, H.V., Rehman, S., Boogerd, F.C., Yilmaz, N., Verma, M. (2014). The Control Analysis of Signal Transduction. In: Aon, M., Saks, V., Schlattner, U. (eds) Systems Biology of Metabolic and Signaling Networks. Springer Series in Biophysics, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38505-6_3

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