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Ocular and Adnexal Lymphoma: Biopsy Techniques

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Ocular and Adnexal Lymphoma

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Correct biopsy technique is critical in the diagnosis and management of ocular and adnexal lymphoma. The decision of what tissue to biopsy should take into account the ease of access to tissue, potential damage to surrounding vital structures, and risk for vision loss. Specific techniques will be reviewed in this chapter for various clinical scenarios including anterior segment, vitreous, subretinal, choroidal, and orbital biopsy.

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References

  • Agrawal P, Dey P, Lal A (2013) Fine-needle aspiration cytology of orbital and eyelid lesions. Diagn Cytopathol. doi:10.1002/dc.22972, PubMed PMID: 23457033

    PubMed  Google Scholar 

  • Akgul H, Otterbach F, Bornfeld N, Jurklies B (2011) Intraocular biopsy using special forceps: a new instrument and refined surgical technique. Br J Ophthalmol 95(1):79–82. doi:10.1136/bjo.2008.148395, PubMed PMID: 21163820

    Article  PubMed  Google Scholar 

  • Cohen VM, Dinakaran S, Parsons MA, Rennie IG (2001) Transvitreal fine needle aspiration biopsy: the influence of intraocular lesion size on diagnostic biopsy result. Eye (Lond) 15(Pt 2):143–147, PubMed PMID: 11339578

    Article  CAS  Google Scholar 

  • Cole CJ, Kwan AS, Laidlaw DA, Aylward GW (2008) A new technique of combined retinal and choroidal biopsy. Br J Ophthalmol 92(10):1357–1360. doi:10.1136/bjo.2008.141697, PubMed PMID: 18664500

    Article  PubMed  CAS  Google Scholar 

  • Coupland SE, Hummel M, Stein H (2002) Ocular adnexal lymphomas: five case presentations and a review of the literature. Surv Ophthalmol 47(5):470–490, Review. PubMed PMID: 12431695

    Article  PubMed  Google Scholar 

  • Covert DJ, Henry CR, Bhatia SK, Croskrey J, Sanchez CR, Han DP (2012) Intraoperative retinal tear formation and postoperative rhegmatogenous retinal detachment in transconjunctival cannulated vitrectomy systems compared with the standard 20-gauge system. Arch Ophthalmol 130(2):186–189. doi:10.1001/archopthalmol.2011.1378, PubMed PMID: 22332210

    Article  PubMed  Google Scholar 

  • Davis JL, Miller DM, Ruiz P (2005) Diagnostic testing of vitrectomy specimens. Am J Ophthalmol 140(5):822–829, PubMed PMID: 16310459

    Article  PubMed  Google Scholar 

  • Dorrepaal SJ, Margolin EA, Wang C (2010) Bilateral pseudohypopyon as a presenting feature of recurrent diffuse large B-cell lymphoma. J Neuroophthalmol 30(1):67–69. doi:10.1097/WNO.0b013e3181ce2c98, PubMed PMID: 20182212

    Article  PubMed  Google Scholar 

  • Eide N, Walaas L (2009) Fine-needle aspiration biopsy and other biopsies in suspected intraocular malignant disease: a review. Acta Ophthalmol 87(6):588–601. doi:10.1111/j.1755-3768.2009.01637.x, Review. PubMed PMID: 19719804

    Article  PubMed  Google Scholar 

  • Finger PT, Papp C, Latkany P, Kurli M, Iacob CE (2006) Anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma. Br J Ophthalmol 90(6):690–692, PubMed Central PMCID: PMC1860244

    Article  PubMed  CAS  Google Scholar 

  • Garrity JA, Henderson JW (eds) (2007) Henderson’s orbital tumors, 4th edn. Lippincott, Philadelphia

    Google Scholar 

  • Gonzales JA, Chan CC (2007) Biopsy techniques and yields in diagnosing primary intraocular lymphoma. Int Ophthalmol 27(4):241–250, Epub 2007 Apr 18. Review. PubMed PMID: 17440686; PubMed Central PMCID: PMC2048742

    Article  PubMed  Google Scholar 

  • Grossniklaus HE, Stulting RD, Gansler T, Aaberg TM Jr (2003) Aspiration cytology of the conjunctival surface. Acta Cytol 47(2):239–246, PubMed PMID: 12685195

    Article  PubMed  Google Scholar 

  • Gündüz K, Shields JA, Shields CL, Eagle RC Jr, Diniz W, Mercado G, Chang W (1999) Transscleral choroidal biopsy in the diagnosis of choroidal lymphoma. Surv Ophthalmol 43(6):551–555, PubMed PMID: 10416797

    Article  PubMed  Google Scholar 

  • Gupta N, Kaur J, Rajwanshi A, Nijhawan R, Srinivasan R, Dey P, Singh U, Gupta P (2012) Spectrum of orbital and ocular adnexal lesions: an analysis of 389 cases diagnosed by fine needle aspiration cytology. Diagn Cytopathol 40(7):582–585. doi:10.1002/dc.21586. Epub 2011 Feb 9, PubMed PMID: 21309008

    Article  PubMed  Google Scholar 

  • Johnston RL, Tufail A, Lightman S, Luthert PJ, Pavesio CE, Cooling RJ, Charteris D (2004) Retinal and choroidal biopsies are helpful in unclear uveitis of suspected infectious or malignant origin. Ophthalmology 111(3):522–528, PubMed PMID: 15019330

    Article  PubMed  Google Scholar 

  • Lim LL, Suhler EB, Rosenbaum JT, Wilson DJ (2005) The role of choroidal and retinal biopsies in the diagnosis and management of atypical presentations of uveitis. Trans Am Ophthalmol Soc 103:84–91; discussion 91–2. PubMed PMID: 17057791; PubMed Central PMCID: PMC1447562

    PubMed  Google Scholar 

  • Margolis R, Brasil OF, Lowder CY, Singh RP, Kaiser PK, Smith SD, Perez VL, Sonnie C, Sears JE (2007) Vitrectomy for the diagnosis and management of uveitis of unknown cause. Ophthalmology 14(10):1893–1897, PubMed PMID: 17509687

    Article  Google Scholar 

  • Martin DF, Chan CC, de Smet MD, Palestine AG, Davis JL, Whitcup SM, Burnier MN Jr, Nussenblatt RB (1993) The role of chorioretinal biopsy in the management of posterior uveitis. Ophthalmology 100(5):705–714, PubMed PMID: 8493014

    PubMed  CAS  Google Scholar 

  • Mashayekhi A, Shields CL, Shields JA (2013) Iris involvement by lymphoma: a review of 13 cases. Clin Experiment Ophthalmol 41(1):19–26. doi:10.1111/j.1442-9071.2012.02811.x, PubMed PMID: 22594613

    Article  PubMed  Google Scholar 

  • Melicher JS (2010) Lateral orbitotomy. In: Levine M (ed) Manual of oculoplastic surgery, 4th edn. Slack Incorporated, Thorofare, pp 289–296

    Google Scholar 

  • Meyer DR, Spoor TC (2010) Anterior orbitotomy. In: Levine M (ed) Manual of oculoplastic surgery, 4th edn. Slack Incorporated, Thorofare, pp 289–296

    Google Scholar 

  • Mruthyunjaya P, Jumper JM, McCallum R, Patel DJ, Cox TA, Jaffe GJ (2002) Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy. Ophthalmology 109(6):1123–1129, PubMed PMID: 12045054

    Article  PubMed  Google Scholar 

  • Peyman GA, Juarez CP, Raichand M (1981) Full-thickness eye-wall biopsy: long-term results in 9 patients. Br J Ophthalmol 65(10):723–726, PubMed PMID: 7317326; PubMed Central PMCID: PMC1039647

    Article  PubMed  CAS  Google Scholar 

  • Rastogi A, Jain S (2001) Fine needle aspiration biopsy in orbital lesions. Orbit 20(1):11–23, PubMed PMID: 12045931

    Article  PubMed  Google Scholar 

  • Sarafzadeh S, Corrêa ZM, Dhamija A, Augsburger JJ, Trichopoulos N (2010) Intraocular lymphoma diagnosed by fine-needle aspiration biopsy. Acta Ophthalmol 88(6):705–710. doi:10.1111/j.1755-3768.2009.01531.x, PubMed PMID: 19604155

    Article  PubMed  Google Scholar 

  • Sen J, Groenewald C, Hiscott PS, Smith PA, Damato BE (2006) Transretinal choroidal tumor biopsy with a 25-gauge vitrector. Ophthalmology 113(6):1028–1031, PubMed PMID: 16751041

    Article  PubMed  Google Scholar 

  • Sharara N, Holden JT, Wojno TH, Feinberg AS, Grossniklaus HE (2003) Ocular adnexal lymphoid proliferations: clinical, histologic, flow cytometric, and molecular analysis of forty-three cases. Ophthalmology 110(6):1245–1254, PubMed PMID: 12799255

    Article  PubMed  Google Scholar 

  • Shields JA, Shields CL (1999) Atlas of orbital tumors. Lippincott Williams and Wilkins, Philadelphia

    Google Scholar 

  • Yeh S, Weichel ED, Faia LJ, Albini TA, Wroblewski KK, Stetler-Stevenson M, Ruiz P, Sen HN, Chan CC, Nussenblatt RB (2010) 25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma. Br J Ophthalmol 94(5):633–638. doi:10.1136/bjo.2009.167940, PubMed PMID: 20447965; PubMed Central PMCID: PMC2928256

    Article  PubMed  Google Scholar 

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Correspondence to Sunil Srivastava MD .

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Srivastava, S. (2014). Ocular and Adnexal Lymphoma: Biopsy Techniques. In: Singh, A. (eds) Ocular and Adnexal Lymphoma. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38499-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-38499-8_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38498-1

  • Online ISBN: 978-3-642-38499-8

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