Skip to main content

Premalignant Conditions of the Lip Actinic Cheilitis

  • Chapter
  • First Online:
Lip Cancer
  • 1273 Accesses

Abstract

Actinic cheilitis (AC), also referred to as actinic cheilosis, actinic keratosis of the lips, and solar elastosis, is a degenerative change of the labial vermilion. It is considered to be a potentially malignant change related to chronic sun exposure that represents a spectrum of histopathologic variables. Actinic refers to the effect that radiant energy can produce chemical changes on tissue, and cheilitis refers to inflammation of the lip. AC is similar in pathophysiology and appearance to its counterpart of the skin, actinic keratosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kaugars GE et al (1999) Actinic cheilitis: a review of 152 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88(2):181–186

    Article  PubMed  CAS  Google Scholar 

  2. Martinez A et al (2005) Expression of apoptotic and cell proliferation regulatory proteins in actinic cheilitis. J Oral Pathol Med 34(5):257–262

    Article  PubMed  CAS  Google Scholar 

  3. Neto Pimentel DR et al (2006) Actinic cheilitis: histopathology and p53. J Cutan Pathol 33(8):539–544

    Article  PubMed  Google Scholar 

  4. Fontes A et al (2009) The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis. J Cutan Pathol 36(11):1151–1156

    Article  PubMed  Google Scholar 

  5. Chou A, Dekker N, Jordan RC (2009) Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(4):535–541

    Article  PubMed  Google Scholar 

  6. Martinez A et al (2008) Epithelial expression of p53, mdm-2 and p21 in normal lip and actinic cheilitis. Oral Oncol 44(9):878–883

    Article  PubMed  CAS  Google Scholar 

  7. Souza LR et al (2011) Immunohistochemical analysis of p53, APE1, hMSH2 and ERCC1 proteins in actinic cheilitis and lip squamous cell carcinoma. Histopathology 58(3):352–360

    Article  PubMed  Google Scholar 

  8. Shah AY, Doherty SD, Rosen T (2010) Actinic cheilitis: a treatment review. Int J Dermatol 49(11):1225–1234

    Article  PubMed  Google Scholar 

  9. Cavalcante AS, Anbinder AL, Carvalho YR (2008) Actinic cheilitis: clinical and histological features. J Oral Maxillofac Surg 66(3):498–503

    Article  PubMed  Google Scholar 

  10. Markopoulos A, Albanidou-Farmaki E, Kayavis I (2004) Actinic cheilitis: clinical and pathologic characteristics in 65 cases. Oral Dis 10(4):212–216

    Article  PubMed  CAS  Google Scholar 

  11. Menta Simonsen Nico M, Rivitti EA, Lourenco SV (2007) Actinic cheilitis: histologic study of the entire vermilion and comparison with previous biopsy. J Cutan Pathol 34(4):309–314

    Article  PubMed  Google Scholar 

  12. Rossoe EW et al (2011) Actinic cheilitis: aesthetic and functional comparative evaluation of vermilionectomy using the classic and W-plasty techniques. An Bras Dermatol 86(1):65–73

    Article  PubMed  Google Scholar 

  13. Sotiriou E et al (2010) Photodynamic therapy with 5-aminolevulinic acid in actinic cheilitis: an 18-month clinical and histological follow-up. J Eur Acad Dermatol Venereol 24(8):916–920

    Article  PubMed  CAS  Google Scholar 

  14. Sotiriou E et al (2011) Sequential use of photodynamic therapy and imiquimod 5% cream for the treatment of actinic cheilitis: a 12-month follow-up study. Br J Dermatol 165(4):888–892

    Article  PubMed  CAS  Google Scholar 

  15. Souza Freitas V et al (2011) Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(3):342–348

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Darren P. Cox DDS, MBA .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Cox, D.P. (2014). Premalignant Conditions of the Lip Actinic Cheilitis. In: Kolokythas, A. (eds) Lip Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38180-5_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-38180-5_3

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38179-9

  • Online ISBN: 978-3-642-38180-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics