The Meniscus: Basic Science

  • H. Pereira
  • J. Silva-Correia
  • J. M. Oliveira
  • R. L. Reis
  • J. Espregueira-MendesEmail author


The menisci are semilunar discs of fibrocartilaginous tissue which play critical roles in knee joint biomechanics [1]. Despite, it has been described in the past as nearly useless with perhaps some minor roles on joint nutrition and stabilization [2]. These complex structures are primarily composed of an interlacing network of collagen fibers (predominantly type I collagen) interposed with cells, and an extracellular matrix (ECM) of proteoglycans and glycoproteins.


Posterior Cruciate Ligament Lateral Meniscus Medial Meniscus Posterior Horn Popliteus Tendon 
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  1. 1.
    McDermott ID, Masouros SD, Amis AA (2008) Biomechanics of the menisci of the knee. Curr Orthopaed 22:193–201CrossRefGoogle Scholar
  2. 2.
    Smillie IS (1972) Injuries of the knee joint, 4th edn. Churcill Livingstone, EdinburghGoogle Scholar
  3. 3.
    Fayard JM, Pereira H, Servien E, Lustig S, Neyret P (2010) Meniscectomy global results-complications. Springer-Verlag, Berlin HeidelbergGoogle Scholar
  4. 4.
    Verdonk PC, Forsyth RG, Wang J et al (2005) Characterisation of human knee meniscus cell phenotype. Osteoarthritis Cartilage 13:548–560PubMedCrossRefGoogle Scholar
  5. 5.
    Kurosawa H, Fukubayashi T, Nakajima H (1980) Load-bearing mode of the knee joint: physical behavior of the knee joint with or without menisci. Clin Orthop Relat Res 283–290Google Scholar
  6. 6.
    Fukubayashi T, Kurosawa H (1980) The contact area and pressure distribution pattern of the knee. A study of normal and osteoarthrotic knee joints. Acta Orthop Scand 51:871–879PubMedCrossRefGoogle Scholar
  7. 7.
    Levy IM, Torzilli PA, Warren RF (1982) The effect of medial meniscectomy on anterior-posterior motion of the knee. J Bone Joint Surg Am 64:883–888PubMedGoogle Scholar
  8. 8.
    Walker PS, Hajek JV (1972) The load-bearing area in the knee joint. J Biomech 5:581–589PubMedCrossRefGoogle Scholar
  9. 9.
    Bourne RB, Finlay JB, Papadopoulos P, Andreae P (1984) The effect of medial meniscectomy on strain distribution in the proximal part of the tibia. J Bone Joint Surg Am 66:1431–1437PubMedGoogle Scholar
  10. 10.
    Brody JM, Hulstyn MJ, Fleming BC, Tung GA (2007) The meniscal roots: gross anatomic correlation with 3-T MRI findings. AJR Am J Roentgenol 188:W446–W450PubMedCrossRefGoogle Scholar
  11. 11.
    Wilmes P, Pape D, Kohn D, Seil R (2007) The reproducibility of radiographic measurement of lateral meniscus horn position. Arthroscopy 23:1079–1086PubMedCrossRefGoogle Scholar
  12. 12.
    Wilmes P, Anagnostakos K, Weth C, Kohn D, Seil R (2008) The reproducibility of radiographic measurement of medial meniscus horn position. Arthroscopy 24:660–668PubMedCrossRefGoogle Scholar
  13. 13.
    Beaupre A, Choukroun R, Guidouin R, Garneau R, Gerardin H, Cardou A (1986) Knee menisci. Correlation between microstructure and biomechanics. Clin Orthop Relat Res 72–75Google Scholar
  14. 14.
    Bullough PG, Munuera L, Murphy J, Weinstein AM (1970) The strength of the menisci of the knee as it relates to their fine structure. J Bone Joint Surg Br 52:564–567PubMedGoogle Scholar
  15. 15.
    Bursac P, Arnoczky S, York A (2009) Dynamic compressive behavior of human meniscus correlates with its extra-cellular matrix composition. Biorheology 46:227–237PubMedGoogle Scholar
  16. 16.
    Killian ML, Lepinski NM, Haut RC, Haut Donahue TL (2010) Regional and zonal histo-morphological characteristics of the lapine menisci. Anat Rec (Hoboken) 293:1991–2000Google Scholar
  17. 17.
    Pereira H, Frias AM, Oliveira JM, Espregueira-Mendes J, Reis RL (2011) Tissue engineering and regenerative medicine strategies in meniscus lesions. Arthroscopy 27:1706–1719PubMedCrossRefGoogle Scholar
  18. 18.
    Pereira H, Frias AM, Caridade SG et al (2011) Cellular and biomechanical segmental characterization of human meniscus. Osteoarthritis Cartilage 19:S205CrossRefGoogle Scholar
  19. 19.
    Kohn D, Moreno B (1995) Meniscus insertion anatomy as a basis for meniscus replacement: a morphological cadaveric study. Arthroscopy 11:96–103PubMedCrossRefGoogle Scholar
  20. 20.
    Gupte CM, Smith A, McDermott ID, Bull AM, Thomas RD, Amis AA (2002) Meniscofemoral ligaments revisited. Anatomical study, age correlation and clinical implications. J Bone Joint Surg Br 84:846–851PubMedCrossRefGoogle Scholar
  21. 21.
    Gupte CM, Bull AM, Thomas RD, Amis AA (2003) The meniscofemoral ligaments: secondary restraints to the posterior drawer. Analysis of anteroposterior and rotary laxity in the intact and posterior-cruciate-deficient knee. J Bone Joint Surg Br 85:765–773PubMedGoogle Scholar
  22. 22.
    Makris EA, Hadidi P, Athanasiou KA (2011) The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials 32:7411–7431PubMedCrossRefGoogle Scholar
  23. 23.
    Herwig J, Egner E, Buddecke E (1984) Chemical changes of human knee joint menisci in various stages of degeneration. Ann Rheum Dis 43:635–640PubMedCrossRefGoogle Scholar
  24. 24.
    Sweigart MA, Athanasiou KA (2001) Toward tissue engineering of the knee meniscus. Tissue Eng 7:111–129PubMedCrossRefGoogle Scholar
  25. 25.
    Cheung HS (1987) Distribution of type I, II, III and V in the pepsin solubilized collagens in bovine menisci. Connect Tissue Res 16:343–356PubMedCrossRefGoogle Scholar
  26. 26.
    McDevitt CA, Webber RJ (1992) The ultrastructure and biochemistry of meniscal cartilage. Clin Orthop Relat Res 252:8–18Google Scholar
  27. 27.
    Ghosh P, Taylor TK (1987) The knee joint meniscus. A fibrocartilage of some distinction. Clin Orthop Relat Res 52–63Google Scholar
  28. 28.
    Scott PG, Nakano T, Dodd CM (1997) Isolation and characterization of small proteoglycans from different zones of the porcine knee meniscus. Biochim Biophys Acta 1336:254–262PubMedCrossRefGoogle Scholar
  29. 29.
    Miller RR, McDevitt CA (1991) Thrombospondin in ligament, meniscus and intervertebral disc. Biochim Biophys Acta 1115:85–88PubMedCrossRefGoogle Scholar
  30. 30.
    Ghadially FN, Thomas I, Yong N, Lalonde JM (1978) Ultrastructure of rabbit semilunar cartilages. J Anat 125:499–517PubMedGoogle Scholar
  31. 31.
    Nakata K, Shino K, Hamada M et al (2001) Human meniscus cell: characterization of the primary culture and use for tissue engineering. Clin Orthop Relat Res S208–S218Google Scholar
  32. 32.
    Melrose J, Smith S, Cake M, Read R, Whitelock J (2005) Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study. Histochem Cell Biol 124:225–235PubMedCrossRefGoogle Scholar
  33. 33.
    Van der Bracht H, Verdonk R, Verbruggen G, Elewaut D, Verdonk P (2007) Cell based meniscus tissue engineering. In: Ashammakhi N, Reis RL, Chiellini E (eds) Topics in Tissue EngineeringGoogle Scholar
  34. 34.
    Gunja NJ, Dujari D, Chen A, Luengo A, Fong JV, Hung CT (2012) Migration responses of outer and inner meniscus cells to applied direct current electric fields. J Orthop Res 30:103–111PubMedCrossRefGoogle Scholar
  35. 35.
    Mauck RL, Martinez-Diaz GJ, Yuan X, Tuan RS (2007) Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Anat Rec (Hoboken) 290:48–58CrossRefGoogle Scholar
  36. 36.
    Brian D, Mackenzie WG, Shim SS, Leung G (1985) The vascular and nerve supply of the human meniscus. Arthroscopy 1:58–62CrossRefGoogle Scholar
  37. 37.
    Arnoczky SP, Warren RF (1982) Microvasculature of the human meniscus. Am J Sports Med 10:90–95PubMedCrossRefGoogle Scholar

Copyright information

© ISAKOS 2013

Authors and Affiliations

  • H. Pereira
    • 1
  • J. Silva-Correia
    • 1
  • J. M. Oliveira
    • 1
  • R. L. Reis
    • 1
  • J. Espregueira-Mendes
    • 1
    Email author
  1. 1.Clínica Espregueira-MendesPortoPortugal

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