Abstract
Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a naturally occurring hydroxystilbene, is considered as an essential anti-oxidative and possessing chemopreventive properties, and is found in various medical plants. It has been proven that resveratrol is a Sirt1 activator and kinds of biological activities. In this paper, we designed and synthesized a series of resveratrol derivatives through a five-step synthetic procedure. Total 11 resveratrol derivatives were prepared from two kinds of hydroxybenzoic acid by methylation and reduction followed by bromination and reaction with triethyl phosphate to get methoxylated diethyl benzylphosphonates, then condensation with a series of aromatic aldehydes by Wittig-Horner reaction to offer the desired compounds in overall yield of about 17.2–48.5 %. These synthesized compounds were characterized on the basis of 1H NMR.
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Acknowledgments
This work was supported by National Natural Science Foundation of China (No: 81072521) and Tianjin University of Science & Technology (No: 20100411).
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Chen, Y., Hu, F., Gao, Y., Ji, N., Liu, W., Hua, E. (2014). Design and Synthesis of Resveratrol Analogs. In: Zhang, TC., Ouyang, P., Kaplan, S., Skarnes, B. (eds) Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Lecture Notes in Electrical Engineering, vol 251. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37925-3_146
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DOI: https://doi.org/10.1007/978-3-642-37925-3_146
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