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Protein Corona: Applications and Challenges

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Protein-Nanoparticle Interactions

Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 15))

Abstract

The protein corona introduces new unexpected applications and shortcomings for the nanoparticles. For instance, it is now well recognized that the protein coating reduces the targeting capability of surface-engineered nanoparticles by screening the active sites of the targeting ligands. Therefore, in this chapter, we will review the advantages and disadvantages of the protein-nanoparticle interaction with the correspondent biological impact. In addition, broad overview of current available data of both in vitro and in vivo protein-nanoparticle interactions is provided.

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering and Materials Science, University of California in Davis, Davis, California, USA

    Masoud Rahman

  2. NanoBio Interactions Laboratory Department of Nanotechnology Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Sophie Laurent

  3. Laboratoire d’Innovation et, d’Analyse de Bioperformance, École Polytechnique de Montréal, Montreal, Québec, Canada

    Nancy Tawil & L’Hocine Yahia

  4. Pasteur Institute of Iran, National Cell Bank NanoBio Interactions Laboratory, Tehran, Iran

    Morteza Mahmoudi

Authors
  1. Masoud Rahman
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  2. Sophie Laurent
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  3. Nancy Tawil
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  4. L’Hocine Yahia
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  5. Morteza Mahmoudi
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Rahman, M., Laurent, S., Tawil, N., Yahia, L., Mahmoudi, M. (2013). Protein Corona: Applications and Challenges. In: Protein-Nanoparticle Interactions. Springer Series in Biophysics, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37555-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-37555-2_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37554-5

  • Online ISBN: 978-3-642-37555-2

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