Nanoparticle and Protein Corona

  • Masoud Rahman
  • Sophie Laurent
  • Nancy Tawil
  • L’Hocine Yahia
  • Morteza Mahmoudi
Part of the Springer Series in Biophysics book series (BIOPHYSICS, volume 15)


Nanoparticles and other nanomaterials are increasingly considered for use in biomedical applications such as imaging, drug delivery, and hyperthermic therapies. Thus, understanding the interaction of nanomaterials with biological systems becomes key for their safe and efficient application. It is increasingly being accepted that the surface of nanomaterials would be covered by protein corona upon their entrance to the biological medium. The biological medium will then see the achieved modified surface of nanomaterials, and therefore further cellular/tissue responses depend on the composition of corona. In this chapter, we describe the corona variations according to the physicochemical properties of nanomaterials (e.g., size, shape, surface charge, surface functional groups, and hydrophilicity/hydrophobicity). Besides the nanomaterials’ effects, the role of environment factors, such as protein source and slight temperature variations, is discussed in details.


Human Serum Albumin Protein Adsorption Iron Oxide Nanoparticles Roswell Park Memorial Institute Fluorescence Correlation Spectroscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Masoud Rahman
    • 1
  • Sophie Laurent
    • 2
  • Nancy Tawil
    • 3
  • L’Hocine Yahia
    • 3
  • Morteza Mahmoudi
    • 4
  1. 1.Department of Chemical Engineering and Materials ScienceUniversity of California in DavisDavisUSA
  2. 2.NanoBio Interactions Laboratory Department of Nanotechnology Faculty of PharmacyTehran University of Medical SciencesTehranIran
  3. 3.Laboratoire d’Innovation et, d’Analyse de BioperformanceÉcole Polytechnique de MontréalMontrealCanada
  4. 4.Pasteur Institute of Iran, National Cell Bank NanoBio Interactions LaboratoryTehranIran

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