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Immunologische Toleranz und ihre Mechanismen

  • Chapter
Allergologie

Zusammenfassung

Die Ursache der Allergie ist immer noch verborgen unter den komplexen Verstrickungen der immunologischen Toleranz – sozusagen die »Blackbox« der Immunologie. Diese immunologische Toleranz ist so komplex, weil sie normalerweise in der Lage ist, harmlose von pathogenen Eindringlingen zu unterscheiden. In den letzten 5 Jahren ist deutlich geworden, dass das Immunsystem Signale aus der Umwelt mit verschiedenen, teilweise erst kürzlich entdeckten Zellen in Zusammenhänge setzt und diese Zellen in unterschiedlichen Differenzierungsschritten in bestimmte Muster einrasten lässt. Gerade das immunologische Gedächtnis ist ein Endprodukt dieser komplexen Verschachtelung und erlaubt dem Organismus schnell und dennoch ausgewogen auf Gefahren zu reagieren. Dieser Abschnitt versucht die wichtigsten Mechanismen, Zellen und Gene in ein gegenwärtiges Bild der Immuntoleranz zusammenzuführen.

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Authors and Affiliations

  1. Zentrum Allergie und Umwelt (ZAUM), Technische Universität und Helmholtz Zentrum München, Biedersteiner Straße 29, 80802, München, Deutschland

    C. B. Schmidt-Weber Prof. Dr. rer. nat.

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  1. C. B. Schmidt-Weber Prof. Dr. rer. nat.
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Editors and Affiliations

  1. Klinikum rechts der Isar, Technischen Universität München, München

    Tilo Biedermann

  2. Städtisches Klinikum Karlsruhe, Karlsruhe

    Werner Heppt

  3. Universitätsklinikum Gießen und Marburg GmbH, Marburg

    Harald Renz

  4. Universitätsklinikum Tübingen, Eberhard Karls Universität, Tübingen

    Martin Röcken

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Schmidt-Weber, C.B. (2016). Immunologische Toleranz und ihre Mechanismen. In: Biedermann, T., Heppt, W., Renz, H., Röcken, M. (eds) Allergologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37203-2_11

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