Abstract
In recent years, the response of, especially, the right ventricle to intense exercise has gained increased interest. In this study, we use the CircAdapt model to evaluate the influence of inter-individual variation of pulmonary vascular resistance during exercise on cardiovascular hemodynamics. We modeled pulmonary vascular resistance as a nonlinear resistive module in which the resistance increases proportionally to stroke volume. We modeled inter-individual variation following normal random distributions. To evaluate the hemodynamic response to exercise, we computed pulmonary artery systolic pressure and end-systolic wall stress. With our modeling strategy, we were able to reproduce the phenomena observed clinically.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
La Gerche, A., MacIsaac, A.I., Burns, A.T., Mooney, D.J., Inder, W.J., Voigt, J.U., Heidbüchel, H., Prior, D.L.: Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function during exercise. J. Appl. Physiol. 109(5), 1307–1317 (2010)
La Gerche, A., Heidbuchel, H., Burns, A.T., Mooney, D.J., Taylor, A.J., Pfluger, H.B., Inder, W.J., Macisaac, A.I., Prior, D.L.: Disproportionate exercise load and remodeling of the athlete’s right ventricle. Med. Sci. Sports Exerc. 43(6), 974–981 (2011)
La Gerche, A., Burns, A.T., Mooney, D.J., Inder, W.J., Taylor, A.J., Bogaert, J., Macisaac, A.I., Heidbuchel, H., Prior, D.L.: Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur. Heart J. 33(8), 998–1006 (2012)
Arts, T., Delhaas, T., Bovendeerd, P., Verbeek, X., Prinzen, F.W.: Adaptation to mechanical load determines shape and properties of heart and circulation: the CircAdapt model. Am. J. Physiol. Heart Circ. Physiol. 288(4), H1943–H1954 (2005)
Lumens, J., Delhaas, T., Kirn, B., Arts, T.: Three-wall segment (TriSeg) model describing mechanics and hemodynamics of ventricular interaction. Ann. Biomed. Eng. 37(11), 2234–2255 (2009)
Barr, R.G., Bluemke, D.A., Ahmed, F.S., Carr, J.J., Enright, P.L., Hoffman, E.A., Jiang, R., Kawut, S.M., Kronmal, R.A., Lima, J.A.C., Shahar, E., Smith, L.J., Watson, K.E.: Percent emphysema, airflow obstruction, and impaired left ventricular filling. N. Engl. J. Med. 362(3), 217–227 (2010)
Holverda, S., Rietema, H., Westerhof, N., Marcus, J.T., Gan, C.T.J., Postmus, P.E., Vonk-Noordegraaf, A.: Stroke volume increase to exercise in chronic obstructive pulmonary disease is limited by increased pulmonary artery pressure. Heart 95(2), 137–141 (2009)
Argiento, P., Chesler, N., Mulè, M., D’Alto, M., Bossone, E., Unger, P., Naeije, R.: Exercise stress echocardiography for the study of the pulmonary circulation. Eur. Respir. J. 35(6), 1273–1278 (2010)
Lumens, J., Blanchard, D.G., Arts, T., Mahmud, E., Delhaas, T.: Left ventricular underfilling and not septal bulging dominates abnormal left ventricular filling hemodynamics in chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Heart Circ. Physiol. 299(4), H1083–H1091 (2010)
West, J.B., Dollery, C.T., Naimark, A.: Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures. J. Appl. Physiol. 19, 713–724 (1964)
Janicki, J.S., Weber, K.T., Likoff, M.J., Fishman, A.P.: The pressure-flow response of the pulmonary circulation in patients with heart failure and pulmonary vascular disease. Circulation 72(6), 1270–1278 (1985)
Kondo, M., Washizu, M., Matsukura, Y., Washizu, T., Miyasaka, K., Takata, M.: Pressure-flow relationship and longitudinal distribution of pulmonary vascular resistance in heartworm-infected dogs. J. Vet. Med. Sci. 65(9), 965–970 (2003)
Jeon, D.S., Luo, H., Iwami, T., Miyamoto, T., Brasch, A.V., Mirocha, J., Naqvi, T.Z., Siegel, R.J.: The usefulness of a 10% air-10% blood-80% saline mixture for contrast echocardiography: Doppler measurement of pulmonary artery systolic pressure. J. Am. Coll. Cardiol. 39(1), 124–129 (2002)
Palau-Caballero, G., Tobon-Gomez, C., Balicevic, V., Butakoff, C., Loncaric, S., Sitges, M., Bijnens, B.H.: Improving Clinical Translation of Cardiovascular Circulatory Models through an Intuitive Graphical User Interface to CircAdapt, Presenting Simulation Results as Clinical Images and Signals. In: Camara, O., Mansi, T., Pop, M., Rhode, K., Sermesant, M., Young, A. (eds.) STACOM 2012. LNCS, vol. 7746, pp. 345–354. Springer, Heidelberg (2013)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Tobon-Gomez, C., Palau-Caballero, G., Sitges, M., Bijnens, B.H. (2013). Exercise Induced Inter-individual Variation of Right Ventricular Pressures: Simulations Using a Modular Model of the Cardiovascular System. In: Camara, O., Mansi, T., Pop, M., Rhode, K., Sermesant, M., Young, A. (eds) Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges. STACOM 2012. Lecture Notes in Computer Science, vol 7746. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36961-2_38
Download citation
DOI: https://doi.org/10.1007/978-3-642-36961-2_38
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-36960-5
Online ISBN: 978-3-642-36961-2
eBook Packages: Computer ScienceComputer Science (R0)