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Nucleic Acid Nanotechnology: Modified Backbones and Topological Polymer Templates

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DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases

Part of the book series: RNA Technologies ((RNATECHN))

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Abstract

DNA-based nanotechnology has revolutionized the construction of nanoscale objects and devices—primarily by using Watson–Crick base-pairing to program the self-assembly (and reaction pathways) of DNA oligomers into branched structures. However, Watson–Crick-controlled self-assembly is not limited to the use of the “natural” d-(deoxy)ribose phosphodiester backbone.

This chapter describes nanoscale objects synthesized from oligomers containing sugars other than d-deoxyribose or linkages other than phosphodiester linkages. This chapter also focuses on using the backbone of DNA as a topological guide for polymer synthesis.

As these chemical modifications profoundly affect the bioavailability, nuclease resistance, protein binding, optoelectronic, and materials properties of nano-objects compared to their “natural” DNA counterparts, they may find great utility in biomedicine.

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Authors and Affiliations

  1. Chemistry Department, St. John’s University, 8000 Utopia Parkway, St Albert’s Hall, Queens, NY, 11439, USA

    Philip Lukeman

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  1. Philip Lukeman
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Correspondence to Philip Lukeman .

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Editors and Affiliations

  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, Berlin, 14195, Berlin, Germany

    Volker A. Erdmann

  2. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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Lukeman, P. (2013). Nucleic Acid Nanotechnology: Modified Backbones and Topological Polymer Templates. In: Erdmann, V., Barciszewski, J. (eds) DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36853-0_9

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