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Nucleic Acid-Based Encapsulations for Cancer Diagnostics and Drug Delivery

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DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases

Part of the book series: RNA Technologies ((RNATECHN))

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Abstract

With the advancements in proteomics, it is now known that molecular abnormalities found in cancerous cells stem mostly from the proteins involved in signaling pathways including growth factors, receptors, intracellular mediators, and transcription factors. These proteins or molecular determinants can be used as potential “targets” or “biomarkers” for cancer diagnosis and treatments. Affinity devices using nucleic acids are getting growing attention due to their superior selectivity, ease in replicability, and much better stability in diverse condition. Molecules like aptamers can form suitable secondary/tertiary structures that can bind to specific biological molecules. These properties of aptamers, or in general nucleic acids, to form secondary structures are utilized to create novel biomedical tools for pathological applications as well as in drug delivery approaches. This chapter focuses on the use of DNA and RNA molecules as nanomechanical devices, and their abilities to transform into numerous structural conformations like nanogrids, cages, tiles, etc. The selective hybridization of nucleic acids to make 2D and 3D constructs for detection and treatment of cancer are discussed.

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Authors and Affiliations

  1. Nano-Bio Lab, University of Texas at Arlington, Arlington, TX, 76019, USA

    Mohammed Arif I. Mahmood, Umair J. M. Khan & Samir M. Iqbal

  2. Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX, 76011, USA

    Mohammed Arif I. Mahmood & Samir M. Iqbal

  3. Nanotechnology Research and Education Center, University of Texas at Arlington, Arlington, TX, 76019, USA

    Mohammed Arif I. Mahmood, Umair J. M. Khan & Samir M. Iqbal

  4. Department of Biology, University of Texas at Arlington, Arlington, TX, 76010, USA

    Umair J. M. Khan

  5. Department of Bioengineering, University of Texas at Arlington, Arlington, TX, 76010, USA

    Samir M. Iqbal

  6. Joint Graduate Studies Committee of Biomedical Engineering Program, University of Texas at Arlington and University of Texas Southwestern Medical Center at Dallas, Arlington, TX, 76010, USA

    Samir M. Iqbal

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  1. Mohammed Arif I. Mahmood
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Correspondence to Samir M. Iqbal .

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  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, Berlin, 14195, Berlin, Germany

    Volker A. Erdmann

  2. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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Mahmood, M.A.I., Khan, U.J.M., Iqbal, S.M. (2013). Nucleic Acid-Based Encapsulations for Cancer Diagnostics and Drug Delivery. In: Erdmann, V., Barciszewski, J. (eds) DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36853-0_7

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