Abstract
Teeth develop from epithelial cells from the mucosal lining of the oral cavity and cranial neural crest-derived ectomesenchymal cells. These latter cells originate at the ectodermal/neuroectodermal junction of the developing brain, extending rostrally from the caudal boundary of the hindbrain and neural tube to the midbrain and caudal forebrain. They give rise to most connective tissues in the craniofacial region including the bones of the calvarium, face and jaws. So, these bones that are formed by mesenchymal cells have an ectodermal/neuroectodermal ancestry – that is why they are also known as ectomesenchyme. The oral epithelium appears to guide the very early stages of tooth formation and sends signals to the adjacent ectomesenchyme inducing odontogenic potential in the latter. Thereafter, the odontogenic ectomesenchyme takes the lead.
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Slootweg, P.J. (2013). Tooth Formation. In: Dental Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36714-4_1
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DOI: https://doi.org/10.1007/978-3-642-36714-4_1
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