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Plasma Fatty Acid Profiles During the First Year in Dogs with and without Hip Dysplasia: Preliminary Results

Chapter

Abstract

At the Military Veterinary Center of Grossetto, where operative dogs from the Italian Army are raised and trained, more than 70 % of the discharges for unfitness are due to articular pathologies like hip and elbow dysplasia. The aim of this study was to investigate fatty acid metabolism of dogs during the growth phase, and its modulation by a fish-based diet. Only 2 out of the 32 subjects were affected by articular pathologies during the study. Still, both subjects had lower levels of arachidonic acid and higher levels of docosahexaenoic acid. Moreover, we observed that the ratio of eicosapentaenoic to docosahexaenoic acids, an indicator of delta-6 desaturase activity, drops dramatically during the first year in the German shepherd.

Keywords

Dog Dysplasia Fatty acids 

Notes

Acknowledgments

This research was supported by the Italian “Ministero della difesa,” grant name: “Ricerca sull’incidenza dell’artrosi nel cane militare e strategia di prevenzione e controllo”.

References

  1. Bligh E, Dyer W (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911–917PubMedCrossRefGoogle Scholar
  2. Fritsch DA, Allen TA, Dodd CE, Jewell DE, Sixby KA, Leventhal PS, Brejda J, Hahn KA (2010) A multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis. J Am Vet Med Assoc 236:535–539PubMedCrossRefGoogle Scholar
  3. Lust G (1997) An overview of the pathogenesis of canine hip dysplasia. J Am Vet Med Assoc 210:1443–1445PubMedGoogle Scholar
  4. Melhus H, Risérus U, Warensjö E, Wernroth L, Jensevik K, Berglund L, Vessby B, Michaëlsson K (2008) A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men. Osteoporos Int 19:929–934PubMedCrossRefGoogle Scholar
  5. Renaville B, Mullen A, Moloney F, Larondelle Y, Schneider YJ, Roche HM (2006) Eicosapentaenoic acid and 3, 10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into cis-9, trans-11-conjugated linoleic acid through different pathways in Caco-2 and T84 cells. Br J Nutr 95:688–695PubMedCrossRefGoogle Scholar
  6. Roush JK, Cross AR, Renberg WC, Dodd CE, Sixby KA, Fritsch DA, Allen TA, Jewell DE, Richardson DC, Leventhal PS, Hahn KA (2010) Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis. J Am Vet Med Assoc 236:67–73PubMedCrossRefGoogle Scholar
  7. SAS Institute Inc. (2010) SAS/IML ® 9.22 User’s Guide. Cary, NC: SAS Institute Inc.Google Scholar
  8. Walters J, Hockett T, Ogilvie G, Fettman M (2010) Polyunsaturated Fatty Acid dietary supplementation induces lipid peroxidation in normal dogs. Vet Med Int, 2010 Article ID 619083, 4 pages. doi: 10.4061/2010/619083
  9. Willis M (1989) Hip dysplasia. In: Willis MB (ed) Genetics of the dog. Howell Book House, New York, pp 144–179Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Centro Militare VeterinarioGrossetoItaly
  2. 2.agn Genetics GmbHDavosSwitzerland
  3. 3.Comando Logistico dell’EsercitoRomaItaly
  4. 4.Ospedale Militare VeterinarioMontelibrettiItaly
  5. 5.Corso Addestramento e Allevamento CaniCastiglione del LagoItaly
  6. 6.Dipartimento Scienze degli AlimentiUdineItaly

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