Nomenclature
EC number
2.2.1.9 (formerly a partial reaction of EC 2.5.1.64)
Systematic name
isochorismate:2-oxoglutarate 4-oxopentanoatetransferase (decarboxylating)
Recommended name
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
Synonyms
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase <2,3> [3,4]
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase <2> [5]
EcMenD <2> [4]
MenD <1,2,3> [1,2,3,4,5]
SEPHCHC synthase <1> [2]
SHCHC synthase <2> [5]
CAS registry number
122007-88-9
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References
Sieminska, E.A.; Macova, A.; Palmer, D.R.; Sanders, D.A.: Crystallization and preliminary X-ray analysis of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexa-diene-1-carboxylate (SHCHC) synthase (MenD) from Escherichia coli. Acta Crystallogr. Sect. F, 61, 489-492 (2005)
Jiang, M.; Cao, Y.; Guo, Z.F.; Chen, M.; Chen, X.; Guo, Z.: Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity. Biochemistry, 46, 10979-10989 (2007)
Priyadarshi, A.; Saleem, Y.; Nam, K.H.; Kim, K.S.; Park, S.Y.; Kim, E.E.; Hwang, K.Y.: Structural insights of the MenD from Escherichia coli reveal ThDP affinity. Biochem. Biophys. Res. Commun., 380, 797-801 (2009)
Dawson, A.; Fyfe, P.K.; Hunter, W.N.: Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-en-olpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase). J. Mol. Biol., 384, 1353-1368 (2008)
Kurutsch, A.; Richter, M.; Brecht, V.; Sprenger, G.; Müller, M.: MenD as a versatile catalyst for asymmetric synthesis. J. Mol. Catal. B, 61, 56-66 (2009)
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Schomburg, D., Schomburg, I. (2013). 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase 2.2.1.9. In: Schomburg, D., Schomburg, I. (eds) Class 2–3.2 Transferases, Hydrolases. Springer Handbook of Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36240-8_33
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