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DNA Nanotechnology and Drug Delivery

Abstract

DNA 3D nanostructures have the promising features to be the universal nanocarriers for smart or targeted drug delivery. In this chapter, we will review recent works on using DNA nanotube, DNA tetrahedron, DNA origami nanotube, and DNA origami nanorobot as drug delivery nanocarriers. Their researches showed that specially designed DNA 3D nanostructures, especially DNA tetrahedron, demonstrated great cell uptaking efficacy and are stable for both in vitro and in vivo drug delivery purpose. The exploratory works on DNA 3D nanocarriers assisted the study on cytosine-phosphate-guanine (CpG)-induced immunostimulation, and SiRNA gene silencing paved the way for DNA 3D nanostructures’ real therapeutic application.

Keywords

  • DNA nanotube
  • DNA tetrahedron
  • DNA origami nanotube
  • DNA nanorobot
  • Folate
  • Cytosine-phosphate-guanine (CpG)
  • SiRNA
  • Gene silencing

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Correspondence to Wanqiu Shen .

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Shen, W. (2013). DNA Nanotechnology and Drug Delivery. In: Fan, C. (eds) DNA Nanotechnology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36077-0_15

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