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Modelling the Effect of Genes on the Dynamics of Probabilistic Spiking Neural Networks for Computational Neurogenetic Modelling

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Part of the Lecture Notes in Computer Science book series (LNBI,volume 7548)

Abstract

Computational neuro-genetic models (CNGM) combine two dynamic models – a gene regulatory network (GRN) model at a lower level, and a spiking neural network (SNN) model at a higher level to model the dynamic interaction between genes and spiking patterns of activity under certain conditions. The paper demonstrates that it is possible to model and trace over time the effect of a gene on the total spiking behavior of the SNN when the gene controls a parameter of a stochastic spiking neuron model used to build the SNN. Such CNGM can be potentially used to study neurodegenerative diseases or develop CNGM for cognitive robotics.

Keywords

  • Gene Regulatory Network
  • Spike Neural Network
  • Spike Neuron Model
  • Gene Regulatory Network Model
  • Probabilistic Spike

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Kasabov, N., Schliebs, S., Mohemmed, A. (2012). Modelling the Effect of Genes on the Dynamics of Probabilistic Spiking Neural Networks for Computational Neurogenetic Modelling. In: Biganzoli, E., Vellido, A., Ambrogi, F., Tagliaferri, R. (eds) Computational Intelligence Methods for Bioinformatics and Biostatistics. CIBB 2011. Lecture Notes in Computer Science(), vol 7548. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35686-5_1

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  • DOI: https://doi.org/10.1007/978-3-642-35686-5_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35685-8

  • Online ISBN: 978-3-642-35686-5

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