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Annual Update in Intensive Care and Emergency Medicine 2013 pp 467–480Cite as

Mesenchymal Stem/Stromal Cells: Opportunities and Obstacles in ARDS

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Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM))

Abstract

The acute respiratory distress syndrome (ARDS) constitutes a major cause of death in critical care worldwide, with mortality rates of 40–60 % even with ongoing advances in care. Despite being the focus of ongoing intensive research efforts for over four decades, there are no pharmacologic therapies for acute lung injury (ALI)/ARDS. The lack of success to date with standard ‘pharmacologic’ approaches suggests the need to consider more complex therapeutic approaches, aimed at reducing early injury while maintaining host immune competence, and facilitating (or at least not inhibiting) lung regeneration and repair.

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Acknowledgement

The authors wish to thank Dr. Jeremy A. Scott for his thoughtful critique of the manuscript.

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Authors and Affiliations

  1. Department of Anesthesia, Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 30 Bond Street, M5B 1W8, Toronto, ON, Canada

    G. F. Curley & J. G. Laffey

  2. Department of Anesthesia, School of Medicine, Clinical Sciences Institute, National University of Ireland, Newcastle Road, Galway, Ireland

    M. Hayes

Authors
  1. G. F. Curley
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  2. M. Hayes
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  3. J. G. Laffey
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Corresponding author

Correspondence to J. G. Laffey .

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Editors and Affiliations

  1. Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium

    Jean-Louis Vincent Prof.

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Curley, G.F., Hayes, M., Laffey, J.G. (2013). Mesenchymal Stem/Stromal Cells: Opportunities and Obstacles in ARDS. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2013. Annual Update in Intensive Care and Emergency Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35109-9_38

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  • DOI: https://doi.org/10.1007/978-3-642-35109-9_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35108-2

  • Online ISBN: 978-3-642-35109-9

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