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Antibiotic Adsorption on CRRT Membranes: Impact on Antibiotic Dosing

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Annual Update in Intensive Care and Emergency Medicine 2013

Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM))

Abstract

Continuous renal replacement therapy (CRRT) is increasingly used in hemodynamically compromised or unstable patients with severe sepsis and septic shock. Adequate antimicrobial treatment is imperative and directly correlated with outcome in these patients. However, the pharmacokinetic behavior of most antibiotic agents during CRRT has not been investigated in depth. Antibiotics may be eliminated from the circulation by convection but also by adhering to the dialysis membrane itself, which may result in subtherapeutic plasma levels. In this context, the emergence of highly adsorptive dialysis membranes, such as the AN69 surface treated (AN69 ST) and the polymethylmetacrilate (PMMA) membranes among others, raises important questions related to antimicrobial therapy.

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Authors and Affiliations

  1. Intensive Care Departement, Vrije Universiteit Brussel, University Hospital, 1090, Brussels, Belgium

    P. M. Honoré, R. Jacobs & H. D. Spapen

Authors
  1. P. M. Honoré
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  2. R. Jacobs
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  3. H. D. Spapen
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Correspondence to P. M. Honoré .

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Editors and Affiliations

  1. Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium

    Jean-Louis Vincent Prof.

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Honoré, P.M., Jacobs, R., Spapen, H.D. (2013). Antibiotic Adsorption on CRRT Membranes: Impact on Antibiotic Dosing. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2013. Annual Update in Intensive Care and Emergency Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35109-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-35109-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-35108-2

  • Online ISBN: 978-3-642-35109-9

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