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Bidirektionale Induktionschemotherapie für Magenkarzinome mit Peritonealmetastasierung

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Regionale Therapie maligner Tumoren

Zusammenfassung

Patienten mit peritonealer Metastasierung durch Magenkrebs suchen zuweilen einen Chirurgen auf, ohne zu wissen, dass sie an einer fortgeschrittenen Erkrankung leiden. Bei 10–20% der zum Zweck einer kurativen Resektion untersuchten Patienten wird bei der Untersuchung des Bauchraums eine Peritonealkarzinose festgestellt. Dies tritt am häufigsten bei Patienten auf, die ein Siegelringzellkarzinom anstelle eines Darmkarzinoms haben. Manchmal weist eine geringe Menge Flüssigkeit bei einem CT-Scan oder einer Ultraschalluntersuchung den Arzt auf eine Peritonealkarzinose hin. Auf dem CT deuten eventuell feine lineare Verdichtungen in Verbindung mit dem Fett des Omentums oder Dünndarmmesenteriums auf eine Peritonealkarzinose (PC) hin.

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Literatur

  1. Sugarbaker PH. Epithelial appendiceal neoplasms. Cancer J. 2009;15:225–35.

    Article  PubMed  Google Scholar 

  2. Preusser P, Wilke H, Achterrath W, et al. Phase II study with the combination etoposide, doxorubicin, and cisplatin in advanced measurable gastric cancer. J Clin Oncol. 1989;7(9):1310–7.

    PubMed  CAS  Google Scholar 

  3. Ajani JA, Ota DM, Jessup JM, et al. Resectable gastric carcinoma. An evaluation of preoperative and postoperative chemotherapy. Cancer. 1991;68:1501–6.

    Article  PubMed  CAS  Google Scholar 

  4. Yonemura Y, Bandou E, Sawa T, Yoshimitsu Y, Endou Y, Sasaki T, et al. Neoadjuvant treatment of gastric cancer with peritoneal dissemination. Eur J Surg Oncol. 2006;32(6):661–5.

    Google Scholar 

  5. Yonemura Y, Bandou E, Kinoshita K, Kawamura T, Takahashi S, Endou Y, et al. Effective therapy for peritoneal dissemination in gastric cancer. Surg Oncol Clin N Am. 2003; 12: 635–48.

    Article  PubMed  Google Scholar 

  6. Yonemura Y, Fujimura T, Fushida S, Takegawa S, Kamata T, Katayama K, et al. Hyperthermochemotherapy combined with cytoreductive surgery for the treatment of gastric cancer with peritoneal dissemination. World J Surg. 1991; 15:530–6.

    Article  Google Scholar 

  7. Hirose K, Katayama K, Iida A, Yamaguchi A, Nakagawara G, Umeda S, et al. Efficacy of continuous hyperthermic peritoneal perfusion for the prophylaxis and treatment of peritoneal metastasis of advanced gastric cancer. Oncology. 1999;57:106–14.

    Article  PubMed  CAS  Google Scholar 

  8. Glehen O, Mithieux F, Osinsky D, Beaujard AC, Freyer G, Guertsch P, et al. Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: a phase II study. J Clin Oncol. 2003;21:799–806.

    Article  PubMed  CAS  Google Scholar 

  9. Sugarbaker PH. Results of treatment of 385 patients with peritoneal surface spread of appendiceal malignancy. Ann Surg Oncol. 1999;6(8):727–31.

    Article  PubMed  CAS  Google Scholar 

  10. Japanese Research Society for Gastric Cancer. The general rules for gastric cancer study. 1st ed. Tokyo: Kanehara Shuppan; 1995.

    Google Scholar 

  11. Sugarbaker PH. Peritonectomy procedures. Ann Surg. 1995;21:29–42.

    Article  Google Scholar 

  12. Yonemura Y, Fujimura T, Fushida S, Fujita H, Bando E, Taniguchi K, et al. Peritonectomy as a treatment modality for patients with peritoneal dissemination from gastric cancer. In: Nakashima T, Yamaguchi T, editors. Multimodality therapy for gastric cancer. Tokyo: Springer; 1999. p. 71–80.

    Google Scholar 

  13. Sugarbaker PH, Yu W, Yonemura Y. Gastrectomy, peritonectomy and perioperative intraperitoneal chemotherapy: the evolution of treatment strategies for advanced gastric cancer. Semin Surg Oncol. 2003;21:233–48.

    Article  PubMed  Google Scholar 

  14. Yonemura Y, Fujimura T, Fushida S, et al. Techniques of peritonectomy for advanced and recurrent gastric cancer with peritoneal dissemination. In: Siewert JR, Roder JD, editors. 2nd International gastric cancer congress. Bologna, Monduzzi; 1997, p 1365–9.

    Google Scholar 

  15. Yonemura Y, Fujimura T, Fushida S, et al. A new surgical approach (peritonectomy) for the treatment of peritoneal dissemination. Hepatogastroenterology. 1999;46:601–9.

    Google Scholar 

  16. Culliford AT, Brooks AD, Sharma S, Saltz LB, Schwartz GK, O'Reilly EM, . Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer. Ann Surg Oncol. 2001; 8:787–95.

    Article  PubMed  Google Scholar 

  17. Glehen O, Kwiatkowski F, Sugarbaker PH, et al. Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study. J Clin Oncol. 2004;22:3284–92.

    Article  PubMed  CAS  Google Scholar 

  18. Yonemura Y, de Aretxabala X, Fujimura T, Fushida S, Katayama K, Bandou E, et al. Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study. Hepato-Gastroenterology. 2001;48:1776–82.

    PubMed  CAS  Google Scholar 

  19. Bandou E, Yonemura Y, Takeshita Y, Taniguchi K, Yasui T, Yoshimitsu Y, et al. Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma. Am J Surg. 1999;178:256–62.

    Article  Google Scholar 

  20. Kubota T, Sasano N, Abe O, Nakao I, Kawamura E, Saito T, et al. Potential of the histoculture drug-response assay to contribute to cancer patient survival. Clin Cancer Res. 1995;1: 1537–43.

    PubMed  CAS  Google Scholar 

  21. Tanaka M, Obata T, Sasaki T. Evaluation of antitumor effects of docetaxel (Taxotere®) on human gastric cancers in vitro and in vivo. Eur J Cancer. 1996;32:226–30.

    Article  Google Scholar 

  22. Newman EM, Lu Y, Kashani-Sabet M, Kesavan V, Scanlon KJ. Mechanisms of cross- resistance to methotrexate and 5-fluorouracil in an A2780 human ovarian carcinoma cell subline resistant to cisplatin. Biochem Pharmacol. 1988; 37:443–7.

    Google Scholar 

  23. Cunliffe WJ. The rationale for early postoperative intraperitoneal chemotherapy for gastric cancer. In: Sugarbaker P, editor. Management of gastric cancer. Boston: Kluwer; 1991. p. 143–57.

    Google Scholar 

  24. Fujimoto S, Takahashi M, Kobayashi K, Kure M, Mutou T, Masaoka H, et al. Relation between clinical and histologic outcome of intraperitoneal hyperthermic perfusion for patients with gastric cancer and peritoneal metastasis. Oncology. 1993;50:338–43.

    Article  PubMed  CAS  Google Scholar 

  25. Morgan RJ, Doroshow JH, Synold T, Lim D, Shibata S, Margolin K, et al. Phase I trial of intraperitoneal Docetaxel in the treatment of advanced malignancies primarily confined to the peritoneal cavity: dose-limiting toxicity and pharmacology. Clin Cancer Res. 2003;9: 5896–901.

    PubMed  CAS  Google Scholar 

  26. Fusida S, Furui N, Kinami S, Ninomiya I, Fujimura T, Nishimura G, et al. Pharmacologic study of intraperitoneal docetaxel in gastric cancer patients with peritoneal dissemination. Jpn J Cancer Chemother. 2002;29:1759– 63.

    Google Scholar 

  27. Malmstrom H, Larsson D, Simonsen E. Phase I study of intraperitoneal carboplatin as adjuvant therapy in early ovarian cancer. Gynecol Oncol. 1990;39:289–94.

    Article  PubMed  CAS  Google Scholar 

  28. Ohno M, Hirokawa M, Hando T. Pharmacokinetics of carboplatin after intraperitoneal administration and clinical effect in ovarian cancer. Jpn J Cancer Chemother. 1992;19:2355– 61.

    CAS  Google Scholar 

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Yonemura, Y., Sugarbaker, P.H. (2013). Bidirektionale Induktionschemotherapie für Magenkarzinome mit Peritonealmetastasierung. In: Aigner, K.R., Stephens, F.O., Vogl, T.J., Padberg, W. (eds) Regionale Therapie maligner Tumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35014-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-35014-6_14

  • Publisher Name: Springer, Berlin, Heidelberg

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