Breast cancer has become a major health problem globally, being the most common female cancer in many parts of the world. In developed countries, the high incidence shows some evidence of plateau, whereas in developing countries, the incidence is generally lower but is on the increase. Whether this will “catch up” with the developed countries remains unknown. As the population base in developing countries is much larger, even a slight increase in cancer incidence means a significant increase in patient number. Henceforth, the investigation and diagnosis of breast lesions is likely to become a major health-care and planning issue. Currently the time-honored triple assessment dictates pathologic evaluation being one of the mandatory assessments of breast lesions. FNAC is expected to play a critical role as it is a much cheaper and quicker investigative modality, and the performance of FNAC does not require special instruments. Widespread use of core needle biopsy may not be financially feasible in some of the health-care systems; hence, FNAC will likely to be the method of choice for many of these regions expecting a larger increase of the number of breast cases. Compared to core biopsy, FNAC is more operator dependent, requiring higher skill level in the proper interpretation.
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Becette V, Lerebours F, Spyratos F et al (2011) Immunomarker studies of fine-needle cytopuncture cell blocks for tumor response prediction after preoperative chemotherapy and prognosis in operable nonmetastatic primary breast carcinoma. Breast J 17:121–128PubMedCrossRefGoogle Scholar
Cano G, Milanezi F, Leitão D et al (2003) Estimation of hormone receptor status in fine-needle aspirates and paraffin-embedded sections from breast cancer using the novel rabbit monoclonal antibodies SP1 and SP2. Diagn Cytopathol 29:207–211PubMedCrossRefGoogle Scholar
Gordon PB, Goldenberg SL, Chan NH (1993) Solid breast lesions: diagnosis with US-guided fine-needle aspiration biopsy. Radiology 189(2):573–580PubMedGoogle Scholar
Lorito Di A, Schmitt F (2011) (Cyto)Pathology and Sequencing: next (or Last) Generation? Diagnostic Cytopathol 40:459–461CrossRefGoogle Scholar
Moriki T, Takahashi T, Ueta S et al (2004) Hormone receptor status and HER2/neu overexpression determined by automated immunostainer on routinely fixed cytologic specimens from breast carcinoma: correlation with histologic sections determinations and diagnostic pitfalls. Diagn Cytopathol 30:251–256PubMedCrossRefGoogle Scholar
Schmitt FC (2011) Molecular cytopathology and flow cytometry: pre-analytical procedures matter. Cytopathology 22:355–357PubMedCrossRefGoogle Scholar
Schmitt FC, Vielh P (2012) Molecular biology and cytopathology. Principles and applications. Annales de pathologie 32:e57–e63CrossRefGoogle Scholar
Tse GM, Tan PH (2010) Diagnosing breast lesions by fine needle aspirate cytology or core biopsy: which is better? Breast Cancer Res Treat 123:1–8PubMedCrossRefGoogle Scholar
Westenend PJ, Sever AR, Beekman-De Volder HJ et al (2001) A comparison of aspiration cytology and core needle biopsy in the evaluation of breast lesions. Cancer 93(2):146–150PubMedCrossRefGoogle Scholar