Zusammenfassung
Die angeborene Immunantwort hat Elemente, die auf allen Köperzellen zu finden sind. Dazu gehören so genannte Mustererkennungsrezeptoren (pattern recognition receptors, PRR). Diese Rezeptoren erkennen Moleküle von Pathoorganismen (pathogen-associated molecular pattern, PAMP) und leiten meist eine Aktivierung der Zelle ein.
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Literatur
Angeborene Immunitt
Balamayooran G, Batra S, Fessler MB, Happel KI, Jeyaseelan S. Mechanisms of neutrophil accumulation in the lungs against bacteria. Am J Respir Cell Mol Biol 2010; 43(1): 5–16
Döring G, Gulbins E. Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease. Cell Microbiol 2009; 11: 208–16
Droemann D, Goldmann T, Branscheid D, Clark R, Dalhoff K, Zabel P et al. Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. Histochem Cell Biol 2003; 119(2): 103–108
Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006; 117(5): 979–987
Kenny EF, O’Neill LA. Signalling adaptors used by Toll-like receptors: an update. Cytokine 2008; 43(3): 342–349
Kerrigan AM, Brown GD. C-type lectins and phagocytosis. Immunobiology 2009; 214(7): 562–575
Inohara, Chamaillard, McDonald C, Nunez G. NOD-LRR proteins: role in host microbial interactions and inflammatory disease. Annu Rev Biochem 2005; 74: 355–383
Lührmann A, Grote K, Stephan M, Tschernig T, Pabst R. Local pulmonary immune stimulation by the Toll-like receptor 2 and 6 ligand MALP- 2 in rats is age dependent. Immunol Lett. 2007; 108: 167–73
Maródi L. Innate cellular immune responses in newborns. Clin Immunol 2006; 118: 137–44
Opitz B, van L, V, Eitel J, Suttorp N. Innate immune recognition in infectious and noninfectious diseases of the lung. Am J Respir Crit Care Med 2010; 181(12): 1294–1309
Pabst R, Tschernig T. Bronchus-associated lymphoid tissue: an entry site for antigens for successful mucosal vaccinations? Am J Respir Cell Mol Biol. 2010; 43: 137–41
Rohmann K, Tschernig T, Pabst R, Goldmann T, Drömann D. Innate immunity in the human lung: pathogen recognition and lung disease. Cell Tissue Res. 2011; 343: 167–74
Tsai KS, Grayson MH. Pulmonary defense mechanisms against pneumonia and sepsis. Curr Opin Pulm Med. 2008; 14(3): 260–5
Tschernig T, Pabst R. What is the clinical relevance of different lung compartments? BMC Pulm Med. 2009; 9: 3–9
Wilkins C, Gale M, Jr. Recognition of viruses by cytoplasmic sensors. Curr Opin Immunol 2010; 22(1): 41–47
Surfactant-Abwehr
Griese M, Ripper J, Sibbersen A, et al. Long-term follow-up and treatment
of congenital alveolar proteinosis. BMC Pediatr. 2011; 11: 7–2
Griese M. Surfactanthomöostase - Grundlagen für die Surfactantsubstitutionstherapie. Monatssehr Kinderheilkd 1992; 140: F2–F12
Griese M, Dietrich P, Potz C, Westerburg B, Bals R, Reinhardt D. Surfactant subfractions during nosocomial infection in ventilated preterm human neonates. Am J Resp Crit Care Med 1996; 153: 398–403
Griese M, Steinecker M, Schumacher S, Braun A, Lohse P, Heinrich S. Children with absent surfactant protein D in bronchoalveolar
lavage have more frequently pneumonia. Pediatr Allergy Immunol. 2008 19(7): 639-47. Epub 2008 Feb 11.
Griese M, Gobran LI, Rooney SA. Surfactant lipid uptake and secretion in type II cells in response to lectins and secretagogues. Am J Physiol. 1991; 261(6 Pt 1): L434–42
Kaltenborn E, Kern S, Frixel S, et al. Respiratory syncytial virus potentiates ABCA3 mutation-induced loss of lung epithelial cell differentiation. Hum Mol Genet. 2012, 21: 2793–806
Ledford JG, Pastva AM, Wright, JR. Collectins link innate and adaptive immunity in allergic airway disease. Innate Immunity 2010; 16(3): 183–190
Robertson B, VanGolde LMG, Batenburg JJ. Pulmonary surfactant. From molecular biology to clinical practice. Elsevier, Amsterdam 1992
Tafel O, Latzin P, Paul K, Winter T, Woischnik M, Griese M. Surfactant proteins SP-B and SP-C and their precursors in bronchoalveolar lavages from children with acute and chronic inflammatory airway disease. BMC Pulm Med 2008; 8: 6
Adaptive Abwehr
Braun-Fahrlander C et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347(12): 869–77
Contoli M et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 2006; 12(9): 1023–6
Holloway JA et al. Detection of house-dust-mite allergen in amniotic fluid and umbilical-cord blood. Lancet 2000; 356(9245): 1900–2
Huh JC et al. Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med 2003; 198(1): 19–30
Latzin P et al. Exposure to moderate air pollution during late pregnancy and cord blood cytokine secretion in healthy neonates. PLoS One 2011, 6(8): e2313–0
Lauener RP et al. Expression of CD14 and Toll-like receptor 2 in farmers‹ and non-farmers‹ children. Lancet 2002; 360(9331): 465–6
Nelson DJ et al. Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility
(Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract. J Exp Med 1994; 179(1): 203–12
Riedler J et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358(9288): 1129–33
Schaub B et al. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol 2009; 123(4): 774-82 e–5
Schaub B, Lauener R, Prescott SL. Immunology and Defence mechanism of the developing lung. Eur Respir Mon 2006; 37: 60–78
Strachan D.P. Hay fever, hygiene, and household size. BMJ 1989; 299(6710): 1259–60
Tschernig T et al. Dendritic cells in the mucosa of the human trachea are not regularly found in the first year of life. Thorax 2001; 56(6): 427–31
Husten und Clearance
Hasani A, Pavia D, Agnew JE, Clarke SW. Regional mucus transport following unproductive cough and forced exspiration technique in patients with airways obstruction. Chest 1994; 105: 1420–1425
King M, Brock G, Lundell C. Clearance of mucus by simulated cough. J Appl Physiol 1985; 58 (6): 1776–1782
Kreyling W, Scheuch G. Clearance of Particles Deposited in the Lungs (chapter 7). In: Gehr P, Heyder J (eds). Particle-Lung Interactions. In: Lung Biology in Health and Disease 2000, Vol. 143, exec. Ed. C. Lenfant: 323–376
Geiser M, Schürch S, Im Hof V, Gehr P. Retention of particles: structural and interfacial aspects. In: Gehr P, Heyder J (eds). Particle-Lung Interactions. In: Lung Biology in Health and Disease 2000, Vol. 143, exec. Ed. C. Lenfant: 291–322
Leith RE. Cough. In: Brain JD, Proctor DI, Reid LM (eds) Respiratory defense mechanisms. Dekker, New York 1977: 545–592
Macklem PT. Physiology of cough. Ann Otol 1974; 83X: 761–768
Oldenburg FA jr., Dolovich MB, Montgomery JM, Newhouse MT. Effects of postdural drainage, exercise, and cough on mucus clearance in chronic bronchitis. Am Rev Respir 1979; Dis 120: 739–745
Robinson M, Regnis JA, Bailey DA, King M, Bautovich GJ, Beye PT. Effect of hypertonic saline, amiloride and cough on mucociliary clearance in patients with cystic fibrosis. Am J Respir Crit Care Med 1996; 153: 1503–1509
Salathe M, O’Riordan TG, Wanner A. Treatment of mucociliary dysfunction. Chest 1996; 110: 1048–1057
Wanner A, Phipps RJ, Kim CS. Mucus clearance: Cilia and cough. In: Chernick V, Mellins RB (eds) Basic mechanisms of pediatric respiratory disease: Cellular and integrative. Dekker, Philadelphia 1991: 361–382
Wildhaber J und Kamin W. Inhalationstherapie im Kindes- und Jugendalter, 2. Aufl. Unimed-Verlag, Bremen 2010
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Drömann, D., Renz, H., Tschernig, T., Griese, M., Schaub, B., Wildhaber, J. (2013). Abwehr. In: von Mutius, E., Gappa, M., Eber, E., Frey, U. (eds) Pädiatrische Pneumologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34827-3_5
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