Magnetic Properties of Lewis Lung Carcinoma and Antitumor Magneto-Sensitive Complex

Abstract

In this study we have examined endogenous magnetic characteristics of Lewis lung carcinoma of C57BL/6 mice and mechano-magneto-chemical synthesized magnetosensitive complex (MC) consisted of magnetic nanoparticles Fe₃O₄ with KCl and antitumor antibiotic anthracycline doxorubicin (DR). Magnetic properties were studied by the method of vibrating magnetometry and electron spin resonance spectroscopy. Lewis lung carcinoma on 14 day after inoculation is weak soft ferromagnetic with saturation magnetic moment m _s = + 0.187 emu/g in contrast to diamagnetic environment tissues (m = – 0.002 emu/g). Lewis lung carcinoma had higher concentration of paramagnetic centers compared to environment tissue. Maximal concentration of paramagnetic centers was observed in MC samples (10¹⁸ mg^− 1). The g-factor for MC increased up to 2.64. DR after mechano-magnetochemical treatment is paramagnetic (m = + 0.068 emu/g at H = 3000 Oe) in contrast to conventional drug which is diamagnetic (m = – 0.200 emu/g).