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Pathology Hinting as the Combination of Automatic Segmentation with a Statistical Shape Model

  • Conference paper

Part of the Lecture Notes in Computer Science book series (LNIP,volume 7512)

Abstract

With improvements in acquisition speed and quality, the amount of medical image data to be screened by clinicians is starting to become challenging in the daily clinical practice. To quickly visualize and find abnormalities in medical images, we propose a new method combining segmentation algorithms with statistical shape models. A statistical shape model built from a healthy population will have a close fit in healthy regions. The model will however not fit to morphological abnormalities often present in the areas of pathologies. Using the residual fitting error of the statistical shape model, pathologies can be visualized very quickly. This idea is applied to finding drusen in the retinal pigment epithelium (RPE) of optical coherence tomography (OCT) volumes. A segmentation technique able to accurately segment drusen in patients with age-related macular degeneration (AMD) is applied. The segmentation is then analyzed with a statistical shape model to visualize potentially pathological areas. An extensive evaluation is performed to validate the segmentation algorithm, as well as the quality and sensitivity of the hinting system. Most of the drusen with a height of 85.5 μm were detected, and all drusen at least 93.6 μm high were detected.

Keywords

  • pathology hinting
  • statistical shape model
  • multi-surface segmentation
  • optical coherence tomography

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© 2012 Springer-Verlag Berlin Heidelberg

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Dufour, P.A., Abdillahi, H., Ceklic, L., Wolf-Schnurrbusch, U., Kowal, J. (2012). Pathology Hinting as the Combination of Automatic Segmentation with a Statistical Shape Model. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2012. MICCAI 2012. Lecture Notes in Computer Science, vol 7512. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33454-2_74

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  • DOI: https://doi.org/10.1007/978-3-642-33454-2_74

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-33453-5

  • Online ISBN: 978-3-642-33454-2

  • eBook Packages: Computer ScienceComputer Science (R0)