Type II Toxin-Antitoxins Loci: The relBE Family
relBE of Escherichia coli K-12 is a paradigm TA locus. Here, I describe the discovery of relBE and review the genetic, physiological, biochemical and structural analyses that have led to important insights into TA biology. Five relBE homologues of K-12 are also described while the 6th (mqsRA) is treated in a separate Chapter. Finally, a discussion of the possible biological functions of relBE and other type II TA loci sets the stage for future work on prokaryotic type II TA loci.
KeywordsPlasmid Stabilization RelE Homolog Persister Cell Brucella Abortus Conditional Cooperativity
This work was supported by the Wellcome Trust. I thank members of the Gerdes group and of the Centre for Bacterial Cell Biology for friendly and stimulating discussions.
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