Abstract
The web-based database TADB offers a comprehensive compilation of both predicted and experimentally supported type II toxin-antitoxin (TA) locus data and genetic features. Here, we examine the distribution and diversity of TADB-recorded TA loci throughout bacterial and archaeal genomes; in particular, those carried by the chromosomal mobile elements, such as prophages and integrative and conjugative elements (ICEs). Then the discussion covers the toxin protein-based TA family classification and the conserved domain pairs found in TA proteins.
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Acknowledgments
This study was supported by grants from the 973 program (2012CB721002), Ministry of Science and Technology, China, the National Natural Science Foundation of China (31170082), and the Program for New Century Excellent Talents in University, Ministry of Education, China (NCET-10-0572).
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Ou, HY., Wei, Y., Bi, D. (2013). Type II Toxin-Antitoxin Loci: Phylogeny. In: Gerdes, K. (eds) Prokaryotic Toxin-Antitoxins. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33253-1_14
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DOI: https://doi.org/10.1007/978-3-642-33253-1_14
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