Skip to main content
SpringerLink
Log in

Lungenmetastasen beim Melanom

  • Chapter
  • First Online:
Lungenmetastasen

  • 1559 Accesses

Zusammenfassung

In kaum einem anderen Gebiet der Onkologie gab es in den letzten Jahren vergleichbare Fortschritte wie in der medikamentösen Therapie des metastasierten Melanoms. Die Lunge ist häufig Erstmanifestationsort einer Metastasierung und von einer solitären Metastase beim Melanom betroffen, wodurch chirurgische Optionen eröffnet werden. Die Integration der Thoraxchirurgie in die neuen multimodalen Behandlungskonzepte ist ein noch offenes Thema. Die Metastasektomie ist als wichtige Indikation bei R0-Option bei einer sorgfältig selektionierten Patientensubgruppe anzusehen. Aufgrund der Chancen der zielgerichteten Melanomtherapie und der relativen Häufigkeit von Lungenmetastasen als Initialmetastasierung beim Melanom ist eine pulmonale oder thorakale Metastasektomie für die histologische Sicherung der Melanommetastasierung und der molekulargenetischen Typisierung des Melanoms häufig indiziert. Die Metastasektomie nach Einsetzen einer Remission durch eine neoadjuvante zielgerichtete Therapie oder Chemotherapie zur Entfernung von Tumorresiduen oder bei progredienten Metastasen in einer mixed response Situation ist eine sinnvolle Zielsetzung. Ferner ist die Einbeziehung der Thoraxchirurgie im Rahmen palliativer Therapiekonzepte bei Lebensqualität einschränkenden, symptomatischen, thorakalen Metastasen unverzichtbar.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 69.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Balch CM, Gershenwald JE, Soong SJ et al (2009) Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol;27(36):6199–6206

    Article  PubMed Central  PubMed  Google Scholar 

  • Balch CM, Soong SJ, Murad TM et al (1983) A multifactorial analysis of melanoma. IV. prognostic factors in 200 melanoma patients with distant metastasis (stage III). J Clin Oncol;1:126–134

    CAS  PubMed  Google Scholar 

  • Brose MS, Volpe P, Feldman M et al (2002) BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 62(23):6997–7000

    CAS  PubMed  Google Scholar 

  • Chapman PB, Hauschild A, Robert C, Haanen JB et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364(26): 2507–2516

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Dalrymple-Hay MJ, Rome PD, Kennedy C et al (2002) Pulmonary metastatic melanoma – the survival benefit associated with positron emission tomography scanning. Eur J Cardiothorac Surg 21(4):611–4; discussion 614–615

    Google Scholar 

  • DasGupta T, Brasfield R (1964) Metastatic melanoma. A Clinicopathological study. Cancer 17:1323–1339

    Article  CAS  PubMed  Google Scholar 

  • Eigentler TK, Caroli UM, Radny P et al (2003) Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials. Lancet Oncol 4: 748–759

    Article  CAS  PubMed  Google Scholar 

  • Enk AH, Nashan D, Rübben A et al (2000) High dose inhalation interleukin-2 therapy for lung metastases in patients with malignant melanoma. Cancer 88(9):2042–2046

    Article  CAS  PubMed  Google Scholar 

  • Fuster D, Chiang S, Johnson G et al (2004) Is 18F-FDG PET more accurate than standard diagnostic procedures in the detection of suspected recurrent melanoma? J Nucl Med 45(8):1323–1327

    PubMed  Google Scholar 

  • Gritters LS, Francis IR, Zasadny KR et al (1993) Initial assessment of positron emission tomography using 2-fluorine-18-fluoro-2-deoxy-D-glucose in the imaging of malignant melanoma. J Nucl Med 34(9):1420–1427

    CAS  PubMed  Google Scholar 

  • Harpole DH Jr, Johnson CM, Wolfe WG et al (1992) Analysis of 945 cases of pulmonary metastatic melanoma. J Thorac Cardiovasc Surg 103(4):743–8; discussion 748–750

    Google Scholar 

  • Hauschild A, Grob JJ, Demidov LV et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380(9839):358–365

    Article  CAS  PubMed  Google Scholar 

  • Hersh EM, O’Day SJ, Ribas A et al (2010) A phase 2 clinical trial of nab-paclitaxel in previously treated and chemotherapy-naive patients with metastatic melanoma. Cancer 116(1):155–163

    CAS  PubMed  Google Scholar 

  • Hodi FS, O’Day SJ, McDermott DF, et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711–723

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kaatsch P, Spix C, Katalinic A, et al (2012) Beiträge zur Gesundheitsberichterstattung des Bundes – Krebs in Deutschland 2007/2008. Robert Koch-Institut

    Google Scholar 

  • Krug B, Dietlein M, Groth W et al (2000) Fluor-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in malignant melanoma. Diagnostic comparison with conventional imaging methods. Acta Radiol 41(5):446–452

    CAS  PubMed  Google Scholar 

  • Lang J, MacKie RM (2005) Prevalence of exon 15 BRAF mutations in primary melanoma of the superficial spreading, nodular, acral, and lentigo maligna subtypes. J Invest Dermatol 125: 575–579

    Article  CAS  PubMed  Google Scholar 

  • Lee CC, Faries MB, Wanek LA et al (2009) Improved survival for stage IV melanoma from an unknown primary site. J Clin Oncol 27(21):3489–3495

    Article  PubMed Central  PubMed  Google Scholar 

  • Leo F, Cagini L, Rocmans Pet al (2000) Lung metastases from melanoma: when is surgical treatment warranted? Br J Cancer. 83(5):569–572

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Little EG, Eide MJ (2012) Update on the current state of melanoma incidence. Dermatol Clin 30(3):355–361

    Article  CAS  PubMed  Google Scholar 

  • Mayerhoefer ME, Prosch H, Herold CJ et al (2012) Assessment of pulmonary melanoma metastases with 18F-FDG PET/CT: which PET-negative patients require additional tests for definitive staging? Eur Radiol 22(11):2451–2457

    Article  PubMed  Google Scholar 

  • Meyer T, Merkel S, Goehl J (2000) Surgical therapy for distant metastases of malignant melanoma. Cancer 89(9):1983–1991

    Article  CAS  PubMed  Google Scholar 

  • Morton DL, Ollila DW, Hsueh EC et al (1999) Cytoreductive surgery and adjuvant immunotherapy: a new management paradigm for metastatic melanoma. CA Cancer J Clin 49(2):101–116, 165

    Google Scholar 

  • Nathanson L, Hall TC, Farber S (1967) Biological aspects of human malignant melanoma. Cancer 20(5):650–655

    Article  CAS  PubMed  Google Scholar 

  • Ollila DW, Stern SL, Morton DL (1998) Tumor doubling time: a selection factor for pulmonary resection of metastatic melanoma. J Surg Oncol 69(4):206–211

    Article  CAS  PubMed  Google Scholar 

  • Omholt K, Platz A, Kanter L, Ringborg U, Hansson J (2003) NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Clin Cancer Res 9: 6483–6488

    CAS  PubMed  Google Scholar 

  • Petersen RP, Hanish SI, Haney JC et al (2007) Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma. J Thorac Cardiovasc Surg 133(1):104–110

    Article  PubMed  Google Scholar 

  • Pfannschmidt J, Egerer G, Bischof M et al (2012) Surgical intervention for pulmonary metastases. Dtsch Arztebl Int 109(40):645–651

    PubMed  Google Scholar 

  • Pflugfelder A, Kochs C, Blum A (2013) Malignant melanoma S3-guideline „diagnosis, therapy and follow-up of melanoma“;. J Dtsch Dermatol Ges 11Suppl 6:1–116, 1–126

    Google Scholar 

  • Rinne D, Baum RP, Hör G et al (1998) Primary staging and follow-up of high risk melanoma patients with whole-body 18F-fluorodeoxyglucose positron emission tomography: results of a prospective study of 100 patients. Cancer 82(9):1664–1671

    Article  CAS  PubMed  Google Scholar 

  • Schuhan C, Muley T, Dienemann H et al (2011) Survival after pulmonary metastasectomy in patients with malignant melanoma. Thorac Cardiovasc Surg 59(3):158–162

    Article  CAS  PubMed  Google Scholar 

  • Smyth EC, Hsu M, Panageas KS et al (2012) Histology and outcomes of newly detected lung lesions in melanoma patients. Ann Oncol 23(3):577–582

    Article  CAS  PubMed  Google Scholar 

  • Tafra L, Dale PS, Wanek LA (1995) Resection and adjuvant immunotherapy for melanoma metastatic to the lung and thorax. J Thorac Cardiovasc Surg Jul;110(1):119–128

    Article  CAS  PubMed  Google Scholar 

  • The International Registry of Lung Metastases (1997) Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 113:37–49

    Article  Google Scholar 

  • Thomford NR, Woolner LB, Clagett OT (1965) The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg 49:357–363

    CAS  PubMed  Google Scholar 

  • Vijuk G, Coates AS (1998) Survival of patients with visceral metastatic melanoma from an occult primary lesion: A retrospective matched cohort study. Ann Oncol 9:419–422

    Article  CAS  PubMed  Google Scholar 

  • Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA et al (2013) Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 369(2):122–133

    Article  CAS  PubMed  Google Scholar 

  • Wong JH, Skinner K, Kim K, et al (1993) The role of surgery in the treatment of nonregionally recurrent melanoma. Surgery; 113:389–394

    CAS  PubMed  Google Scholar 

  • Wornom IL 3rd, Smith JW, Soong SJ et al (1986) Surgery as palliative treatment for distant metastases of melanoma. Ann Surg 204(2):181–185

    Article  PubMed Central  PubMed  Google Scholar 

  • Xing Y, Bronstein Y, Ross MI et al (2011) Contemporary diagnostic imaging modalities for the staging and surveillance of melanoma patients: a meta-analysis. J Natl Cancer Inst 103(2):129–142

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Dermatologie, Allergologie und Venerologie, Universitätsklinikum Schleswig Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland

    M. Mohr & P. Terheyden

Authors
  1. M. Mohr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Terheyden
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Mohr .

Editor information

Editors and Affiliations

  1. Klinik für Allgemeine, Viszerale, Thorax, Missionsärztliche Klinik, Würzburg, Germany

    Stefan Limmer

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mohr, M., Terheyden, P. (2015). Lungenmetastasen beim Melanom. In: Limmer, S. (eds) Lungenmetastasen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32982-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-32982-1_15

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-32981-4

  • Online ISBN: 978-3-642-32982-1

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation