Abstract
In this paper we propose a new model of cell cycle simulator which will be used to analyse checkpoint response in multicellular tumor spheroids. Whereas most of the models are phase orientated, our model integrates environmental parameters and checkpoint responses that are required to control cell cycle progression. We will present in this paper our work under progress and the different experiments to be performed in order to validate our cell cycle simulator.
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References
Boutros, R., Lobjois, V., Ducommun, B.: CDC25 phosphatases in cancer cells: key players? Good targets? Nature Reviews Cancer 7(7), 495–507 (2007)
Chavoya, A., Duthen, Y.: A cell pattern generation model based on an extended artificial regulatory network. Biosystems 94(1-2), 95–101 (2008)
Cussat-Blanc, S., Pascalie, J., Luga, H., Duthen, Y.: Morphogen positioning by the means of a hydrodynamic engine. In: Artificial Life XII. MIT Press, Cambridge (2010)
Elledge, S.: Cell cycle checkpoints: preventing an identity crisis. Science 274(5293), 1664 (1996)
Frongia, C., Lorenzo, C., Gianni, F., Prevost, G., Ducommun, B., Lobjois, V.: 3D imaging of the response to CDC25 inhibition in multicellular spheroids. Cancer Biology & Therapy 8(23) (2009)
Hoehme, S., Drasdo, D.: A cell-based simulation software for multicellular systems. Bioinformatics (2010)
Kunz-Schughart, L., Freyer, J., Hofstaedter, F., Ebner, R.: The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. Journal of Biomolecular Screening 9(4), 273 (2004)
Sauro, H., Harel, D., Uhrmacher, A., Hucka, M., Kwiatkowska, M., Shaffer, C., Mendes, P., Stromback, L., Tyson, J.: Challenges for modeling and simulation methods in systems biology. In: Proceedings of the Winter Simulation Conference, WSC 2006, pp. 1720–1730 (2006)
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© 2012 ICST Institute for Computer Science, Social Informatics and Telecommunications Engineering
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Pascalie, J., Luga, H., Lobjois, V., Ducommun, B., Duthen, Y. (2012). A Checkpoint-Orientated Modelling for Cell Cycle Simulation. In: Suzuki, J., Nakano, T. (eds) Bio-Inspired Models of Network, Information, and Computing Systems. BIONETICS 2010. Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, vol 87. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32615-8_6
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DOI: https://doi.org/10.1007/978-3-642-32615-8_6
Publisher Name: Springer, Berlin, Heidelberg
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