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The Plant SNX Family and Its Role in Endocytosis

  • Enric Zelazny
  • Rumen Ivanov
  • Thierry Gaude
Chapter

Abstract

Separation of functions within the cytoplasm of the eukaryotic cell has resulted in the development of a highly dynamic network of membranous compartments. Among them, the endosomes represent a crossing point for the major cellular trafficking pathways. Indeed, they are responsible for the communication between the cellular compartments, as well as between the cell and its environment, through the regulation of signalling networks and transport of material. The proteins from the sorting nexin (SNX) family have an established role as major regulators of endosomal protein transport in mammals, insects, worms, and yeast. By contrast, research on plant SNXs has been initiated relatively recently. Despite that, the accumulated knowledge suggests that plant SNXs may have evolved different mechanisms of action and might work in a different protein complex environment, compared to their yeast and animal counterparts. In this chapter, we highlight both common and specific characteristics of plant SNX protein function and regulation in comparison to the well-studied mammalian SNX machinery.

Keywords

Epidermal Growth Factor Receptor Retromer Complex Lytic Vacuole Epidermal Growth Factor Receptor Degradation Vacuolar Sorting Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

BAR

Bin/Amphiphysin/Rvs domain

C-ter

Nexin C-terminal domain

MIT

Microtubule interacting domain

F

Forkhead-associated domain

FERM

4.1/Ezrin/Radixin/Moesin domain

Kinesin

Kinesin motor domain

PDZ

PSD95/Dlg1/Zo-1 domain

PIN

Pin-formed

PX

PHOX homology domain

PXA

PHOX associated domain

RAB

Rab5-binding domain

RAS 

Ras-association domain

RGS

Regulator of G-protein signalling domain

RHO

RhoGAP domain

SH3

Src Homology 3 domain

SNX

Sorting nexin

SRK

S locus receptor kinase

VPS

Vacuolar protein sorting

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Authors and Affiliations

  1. 1.Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Unité Mixte de Service 3444 BioSciences Gerland-Lyon SudUniversité Claude Bernard Lyon I, Ecole Normale Supérieure de LyonLyonFrance
  2. 2.Department of Plant BiologySaarland UniversitySaarbrueckenGermany

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