A Historic Overview of the Metal-Catalyzed Cross-Coupling Reactions

  • Yasushi NishiharaEmail author
Part of the Lecture Notes in Chemistry book series (LNC, volume 80)


The main focus of this publication is the innovation of new synthetic reactions that can form various carbon–carbon bonds with high selectivity. The use of transition-metal-catalyzed cross-coupling reactions of organic electrophiles with organometallic nucleophiles started with the discovery of Kumada–Tamao–Corriu coupling in 1972—the reaction of organic halides and organomagnesium compounds under nickel catalysis. Combining fragments with a series of carbon centers into one segment, the transition-metal-catalyzed cross-coupling reactions have long been industrially utilized toward the synthesis of functional materials such as agricultural chemicals, pharmaceuticals, and polymers.


Cross-coupling Transition metal catalysts Organic halides Organometallic nucleophiles Carbon-carbon bond formation 


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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and TechnologyOkayama UniversityOkayamaJapan

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