Computational Study of Diseases Associated with Protein Aggregation
A number of diseases such as the Alzheimer’s disease, Creutzfeldt-Jakob disease, type-2 diabetes are believed to be associated with the aggregation of proteins and amyloid peptides. In this mini-review we discuss general factors that govern the aggregation of polypeptide chains. It is shown that the extent of population of an ensemble of fibril-prone structures in the spectrum of conformations of an isolated protein, is the major determinant of fibril formation rates. Presently, available drugs help to mask the symptoms, but do not treat aggregation-associated diseases making it vital to develop drugs to cope them. Recent progress on design of topleads for the Alzheimer’s disease will be covered.
KeywordsAggregation Alzheimer’s disease drug design polyphenols
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