Symmetry and Folded Structures of Biomolecules

  • T. X. Hoang
  • N. T. T. Nhung
  • J. R. Banavar
  • A. Maritan
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 49)

Abstract

Our work suggests that protein native state structures occupy a novel phase of matter corresponding to the marginally compact conformations of a flexible tube. This phase arises from common attributes of proteins and is independent of amino acid sequences. Our approach provides a simple and unified framework to understand protein folding and amyloid formation. With a constraint on the local radius of curvature, the tube model is also shown to have ground state conformations similar to that of DNA toroids.

Keywords

protein folding amyloid formation tube model buried area marginally compact phase DNA toroid 

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Copyright information

© IFMBE 2013

Authors and Affiliations

  • T. X. Hoang
    • 1
  • N. T. T. Nhung
    • 1
  • J. R. Banavar
    • 2
  • A. Maritan
    • 3
  1. 1.Institute of PhysicsVietnam Academy of Science and TechnologyHanoiVietnam
  2. 2.College of Computer, Mathematical and Natural SciencesUniversity of MarylandCollege ParkUSA
  3. 3.Dipartimento di Fisica “G. Galilei”Universita di PadovaPadovaItalia

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