Structural Bioinformatics Approaches to Chemical Senses

  • Alejandro Giorgetti
Part of the IFMBE Proceedings book series (IFMBE, volume 49)


A deep characterization of the molecular mechanisms underlying the functioning of the receptors involved in chemical sensing, is fundamental for gaining insights into the way our cells communicate with the external world. Unfortunately, the paucity of experimental structural information hampers such characterization. Protein structural bioinformatics, combined with computational biology and experimental techniques is the key to face these challenges. Here I will show our recent works regarding the bitter-taste signaling pathway. Moreover, I will also present some elements of the state of art of membrane protein structural bioinformatics field.


chemical senses structural bioinformatics docking bitter taste receptors 


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Copyright information

© IFMBE 2013

Authors and Affiliations

  1. 1.Department of BiotechnologyUniversity of VeronaVeronaItaly
  2. 2.German Research School for Simulation ScienceFZ-Jülich and RWTH AachenJülichGermany

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