Diffuse Optical Tomography and Biophysical Modeling of the Aging Brain
Diffuse optical imaging (DOI) of the brain has emerged as a new neuroimaging technique that is seeing growing applications in brain research. The technique’s simplicity, lower cost and applicability to children have contributed to its popularity. However, poor quantification of local hemodynamic changes based on optical signals remains a major hurdle and significant efforts are still being pursued to better understand how to recover accurate images of functional activation, generate statistical maps and recognize the limitations of DOI. In the context of aging, further confounds arise due to anatomical and physiological changes that must be accounted for in the signal modeling. In this work, DOI signals are revisited in this context. In particular we investigate the diffusion path length factor and its modifications with age.
KeywordsDiffuse Optical Imaging Aging
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