Blood Separation Device Based on Microstructures in Microchannels
In this paper, plasma extraction device based on microstructure in microchannels was presented. Also, we analyzed the blood flow according to blood transportation methods for application of blood separation. The microchannels for blood separation were designed blood cell channel, plasma channel and separation channel. The separation channel to separate the plasma was performed the role of micro filter based. The overall shape of microchannels was designed to spiral shape. Spiral microchannel was designed for prevention of blood cell cross-over from blood cell channel to plasma channel and clogging. Microchannels were made of polymethylsiloxane which is optically transparent. Blood sample was diluted with phosphate buffered saline at the ratio of 1:3. Characteristics of blood cell flow through microchannel, also, were observed with respect to two different blood transportation methods including pushing by syringe pump and pulling by vacuum pump. As results, blood flow driven by vacuum pump (pulling) was slower than that driven by syringe pump (pushing), but almost no blood cell was crossover from blood cell channel to plasma channel in pulling transportation method.
KeywordsSpiral microchannel Microstructure Blood separation device Plasma extraction
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