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Blood Separation Device Based on Microstructures in Microchannels

  • Kang Il Byun
  • Hyun Chul Bang
  • Hyung Jin Kim
  • Eui Don Han
  • Young Ho Seo
  • Byeong Hee Kim
Part of the IFMBE Proceedings book series (IFMBE, volume 49)

Abstract

In this paper, plasma extraction device based on microstructure in microchannels was presented. Also, we analyzed the blood flow according to blood transportation methods for application of blood separation. The microchannels for blood separation were designed blood cell channel, plasma channel and separation channel. The separation channel to separate the plasma was performed the role of micro filter based. The overall shape of microchannels was designed to spiral shape. Spiral microchannel was designed for prevention of blood cell cross-over from blood cell channel to plasma channel and clogging. Microchannels were made of polymethylsiloxane which is optically transparent. Blood sample was diluted with phosphate buffered saline at the ratio of 1:3. Characteristics of blood cell flow through microchannel, also, were observed with respect to two different blood transportation methods including pushing by syringe pump and pulling by vacuum pump. As results, blood flow driven by vacuum pump (pulling) was slower than that driven by syringe pump (pushing), but almost no blood cell was crossover from blood cell channel to plasma channel in pulling transportation method.

Keywords

Spiral microchannel Microstructure Blood separation device Plasma extraction 

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Copyright information

© IFMBE 2013

Authors and Affiliations

  • Kang Il Byun
    • 1
  • Hyun Chul Bang
    • 1
  • Hyung Jin Kim
    • 1
  • Eui Don Han
    • 1
  • Young Ho Seo
    • 1
  • Byeong Hee Kim
    • 1
  1. 1.Medical & Bio-Materials Research Center and Dept. of Mechanical and Mechatronics EngineeringKangwon National UniversityChuncheonSouth Korea

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