Effect of Defatted Dabai (Canarium Odontophyllum Miq.) Pulp Ingestion on Lipid Peroxidation and Antioxidant Status of Hypercholesterolemic-Induced Rabbits
Antioxidant activity of Dabai (Canarium odontophyllum Miq.) pulp polyphenols was observed in animal model to investigate its potential in reducing in vivo lipid peroxidation. Dried fullfat and defatted Dabai pulp were prepared and administered daily to hypercholesterolemicinduced rabbits (0.5% dietary cholesterol) at 5% of purified diet, besides a group receiving statin (10mg/kg/day) for 56 days. All groups were induced with hypercholesterolemia except in negative control. At the end of experimental period, the in vivo antioxidative capacities of Dabai pulp were evaluated using assays; TBARS, SOD, GPx and TAS in whole blood and plasma samples of animals. Results indicated that defatted- and fullfat-Dabai pulp significantly reduced 36% and 15% plasma MDA (relative to without treatment [PC]), respectively while only 4% insignificant reduction was due to statin. On the contrary, plasma TAS levels were 76% and 66.2%, significantly higher (than without treatment) attributable to defatted and fullfat Dabai parts supplementation, respectively as compared to 9% insignificant reduction in statin group. Both pulps also caused marked increments in activity of enzymes especially SOD thus suggesting the strong in vivo antioxidant capacities of Dabai pulp (defatted, especially) as future active pharmaceutical ingredient.
KeywordsDabai hypercholesterolemia rabbit artherosclerosis polyphenols
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