Biophysical Assessment of Skin Desquamation and Scaliness Using Tape Strips and Adhesive Discs

  • Kristien De Paepe
  • Yvan Vander Heyden
  • Vera Rogiers


An essential part of normal epidermal physiology is skin desquamation, the loss of single corneocytes and fine flakes at the stratum corneum (SC) surface, also called desquamatio insensibilis. Dry skin conditions – characterized by a brittle, flaky, and even fissured appearance of the upper layers – are linked to abnormal corneocytes cohesion and skin desquamation. Also a decrease in skin moisturization is observed.

Different technologies to determine skin desquamation exist. They can be used to assess skin scaliness and represent an interesting tool for claim substantiation of cosmetic products in relation to dry skin.

The scope of this chapter is to focus on the description of Corneofix® strips and D-SQUAME® discs, both adhesive tape materials that are applicable in tape-stripping protocols and for the characterization of SC desquamation and the extent of scaliness. A better understanding of these SC parameters offers opportunities for innovative product development for preventing and elevating dry, scaly skin conditions.


Stratum Corneum Test Zone Skin Hydration Stratum Corneum Lipid Adhesive Disc 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Arbitrary units


Desquamation index






Lower leg


Natural moisturizing factors


Stratum corneum





The authors would like to thank Goedele Alaerts and Hayate Hajioui for their valuable practical assistance during skin measurements. Part of the described research work was supported by a grant of IWT-Vlaanderen – Flemish Institute for the Promotion of Scientific-Technological Research in Industry.


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Copyright information

© Springer Berlin Heidelberg 2014

Authors and Affiliations

  • Kristien De Paepe
    • 1
  • Yvan Vander Heyden
    • 2
  • Vera Rogiers
    • 3
  1. 1.Department of Toxicology, Dermato-Cosmetology and Pharmacognosy, Department of Analytical Chemistry and Pharmaceutical Technology, Center for Pharmaceutical Research (CePhar), Faculty of Medicine and PharmacyVrije Universiteit Brussel (VUB)BrusselsBelgium
  2. 2.Department of Analytical Chemistry and Pharmaceutical Technology, Center for Pharmaceutical Research (CePhar), Faculty of Medicine and PharmacyVrije Universiteit Brussel (VUB)BrusselsBelgium
  3. 3.Department of Toxicology, Dermato-Cosmetology and Pharmacognosy, Center for Pharmaceutical Research (CePhar), Faculty of Medicine and PharmacyVrije Universiteit Brussel (VUB)BrusselsBelgium

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