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Corneosurfametry and Corneoxenometry

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Non Invasive Diagnostic Techniques in Clinical Dermatology

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Abstract

Corneosurfametry and corneoxenometry are two related investigative methods allowing safe assessment of some irritation potential of surfactants and other xenobiotics, respectively. The method entails harvesting a sheet of the stratum corneum using the cyanoacrylate skin surface procedure. The neat or diluted test product is applied ex vivo for a given period of time at defined temperatures. The material is then rinsed and stained, and the color is measured using reflectance colorimetry in the L*a*b* system. The more the color is intense, the more the product is at risk of in vivo irritation.

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Acknowledgements

This work was supported by a grant from the “Fonds d’Investissement de la Recherche Scientifique” of the University Hospital of Liège. No other sources of funding were used to assist in the preparation of this manuscript. The authors have no conflicts of interest that are directly relevant to the content of this review. The authors appreciate the excellent secretarial assistance of Mrs. Ida Leclercq and Marie Pugliese.

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Authors and Affiliations

  1. Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liège, CHU, Sart Tilman, Liège, B-4000, Belgium

    Gérald E. Piérard MD, PhD, Claudine Piérard-Franchimont & Marie-Annick Reginster

Authors
  1. Gérald E. Piérard MD, PhD
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  2. Claudine Piérard-Franchimont
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  3. Marie-Annick Reginster
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Corresponding author

Correspondence to Gérald E. Piérard MD, PhD .

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Editors and Affiliations

  1. Clinical Dermatology, San Gallicano Dermatological Institute, Rome, Roma, Italy

    Enzo Berardesca

  2. Dermatology, University of California San Francisco, San Francisco, CA, California, USA

    Howard I. Maibach

  3. Proderm, Schenefeld/Hamburg, Germany

    Klaus-Peter Wilhelm

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Piérard, G.E., Piérard-Franchimont, C., Reginster, MA. (2014). Corneosurfametry and Corneoxenometry. In: Berardesca, E., Maibach, H., Wilhelm, KP. (eds) Non Invasive Diagnostic Techniques in Clinical Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32109-2_23

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  • DOI: https://doi.org/10.1007/978-3-642-32109-2_23

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  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-32109-2

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