Palladium 1,2-Migration in the Heck Reaction

  • Thomas Meyer Gøgsig
Part of the Springer Theses book series (Springer Theses)


A more thorough investigation of the palladium 1,2-migration in the Heck reaction was desired, in order to clarify the underlying factors affecting the migratory process. In particular, full control of the isomerization of the 1,3-dienes obtained from the Heck reaction of alkenyl C–O coupling partners and electron deficient olefins would be of high interest. This would in turn represent a novel approach towards the construction of linear disubstituted dienes starting from 1,1-disubstituted alkenyl electrophiles.


Oxidative Addition Heck Reaction Silyl Ether Aryl Chloride Crude Reaction Mixture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Zhao J, Yue D, Campo MA, Larock RC (2007) J Am Chem Soc 129:5288CrossRefGoogle Scholar
  2. 2.
    Mota AJ, Dedieu A (2006) Organometallics 25:3130CrossRefGoogle Scholar
  3. 3.
    Li B–J, Yu D–G, Sun C–L, Shi Z–J (2011) Chem Eur J 17:1728Google Scholar
  4. 4.
    Hansen AL, Ebran J–P, Gøgsig TM, Skrydstrup T (2006) Chem Commun 4137Google Scholar
  5. 5.
    Hansen AL, Ebran J–P, Gøgsig TM, Skrydstrup T (2007) J Org Chem 72:6464Google Scholar
  6. 6.
    Gauthier D, Beckendorf S, Gøgsig TM, Lindhardt AT, Skrydstrup T (2009) J Org Chem 74:3536CrossRefGoogle Scholar
  7. 7.
    Hansen AL, Skrydstrup T (2005) Org Lett 7:5585CrossRefGoogle Scholar
  8. 8.
    Coe JW (2000) Org Lett 2:4205CrossRefGoogle Scholar
  9. 9.
    Martin R, Buchwald SL (2008) Acc Chem Res 41:1461CrossRefGoogle Scholar
  10. 10.
    Walker SD, Bareder TE, Martinelli JR, Buchwald SL (2004) Angew Chem Int Ed 43:1871CrossRefGoogle Scholar
  11. 11.
    Barder TE (2006) J Am Chem Soc 128:898CrossRefGoogle Scholar
  12. 12.
    Schnyder A, Indolese AF, Studer M, Blaser H-U (2002) Angew Chem Int Ed 41:3668CrossRefGoogle Scholar
  13. 13.
    Amatore C, Jutand A (1999) J Organomet Chem 576:254CrossRefGoogle Scholar
  14. 14.
    Hansen AL, Ebran J-P, Ahlquist M, Norrby P-O, Skrydstrup T (2006) Angew Chem Int Ed 45:3349CrossRefGoogle Scholar
  15. 15.
    Littke AF, Fu GC (2001) J Am Chem Soc 123:6989CrossRefGoogle Scholar
  16. 16.
    Yu J–Y, Shimizu R, Kuwano R (2010) Angew Chem Int Ed 49:6396Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Chemistry Aarhus UniversityAarhus CDenmark

Personalised recommendations