D-Xylitol pp 325-342 | Cite as

Medical Applications of Xylitol: An Appraisal

  • Annelisa Farah da Silva
  • Aline Siqueira Ferreira
  • Silvio Silvério da Silva
  • Nádia Rezende Barbosa RaposoEmail author


Xylitol is a sugar alcohol, normally produced by mammal metabolism, which has a great (and increasing) applicability in food and pharmaceutical industries due to its intriguing and proper characteristics. The most explored area is oral health, due to its non- and anti-cariogenic properties, followed by its use as a sweetener. Moreover, some other applicabilities in the medical area can be found in literature and patents, such as the use in the treatment and/or prevention of acute otitis media, respiratory diseases, parenteral nutrition, atopic dermatitis, wound repairing, gastrointestinal infections, osteoporosis, anti-aging and inflammatory processes. Market usage of xylitol for over 20 years, accompanied by toxicological studies, corroborated its safety for medical purposes. A great number of recent studies demonstrate that xylitol can be used to develop pharmaceutical products. Especially because of its activity against microorganisms, xylitol medical applications are still an important point for studies, with potential for novel medical applications in the upcoming years.


Xylitol Medical applications Antimicrobial action Dietetic usage 



The financial scholarship provided by CAPES and financial support provided by FAPESP, CNPq and FAPEMIG are gratefully acknowledged.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Annelisa Farah da Silva
    • 1
  • Aline Siqueira Ferreira
    • 1
  • Silvio Silvério da Silva
    • 2
  • Nádia Rezende Barbosa Raposo
    • 1
    Email author
  1. 1.Faculty of Pharmacy, University Campus—Center of Research and Innovation in Health Sciences (Núcleo de Pesquisa e Inovação em Ciências da Saúde—NUPICS)Federal University of Juiz de ForaJuiz de Fora-MGBrazil
  2. 2.Department of Biotechnology, Engineering School of LorenaUniversity of Sao PauloLorena-SPBrazil

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