Complement Deficiencies

  • Kathleen Sullivan
  • Martha M. Eibl
  • Melinda Erdős
  • László Maródi
  • Hermann M. Wolf
  • Maryam Mahmoudi
  • Nima Rezaei


Although the complement system was first described at the turn of the twentieth century, it was not until 1960 that the first patient with a genetically determined complement deficiency was identified. Since then, deficiencies have been described for nearly all of the components of the complement system. Individuals with genetically determined complement deficiencies have a variety of clinical presentations. Most patients present with an increased susceptibility to infections, others with a variety of rheumatic diseases, still others with angioedema, and in rare instances, patients may even be asymptomatic. The elucidation of the pathophysiological basis for the different clinical presentations of complement-deficient individuals has contributed to a better understanding of the physiological role of complement in normal individuals.


Correct Answer Hemolytic Uremic Syndrome Complement Component Meningococcal Disease Neisseria Meningitidis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Kathleen Sullivan
    • 1
  • Martha M. Eibl
    • 2
  • Melinda Erdős
    • 3
  • László Maródi
    • 3
  • Hermann M. Wolf
    • 2
  • Maryam Mahmoudi
    • 4
  • Nima Rezaei
    • 5
    • 6
    • 7
  1. 1.Division of Allergy and ImmunologyChildren’s Hospital of Philadelphia, University of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of PediatricsImmunological Outpatient Clinic, Biomedical Research InstituteViennaAustria
  3. 3.Department of Infectious and Pediatric ImmunologyMedical and Health Science Center, University of DebrecenDebrecenHungary
  4. 4.Department of Nutrition and Biochemistry, School of Public HealthTehran University of Medical SciencesTehranIran
  5. 5.Department of ImmunologyResearch Center for Immunodeficiencies, Children’s Medical Center HospitalTehranIran
  6. 6.Molecular Immunology Research CenterTehranIran
  7. 7.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran

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